TY - JOUR
T1 - Dementia-Related Functional Disability in Moderate to Advanced Parkinson's Disease
T2 - Assessment Using the World Health Organization Disability Assessment Schedule 2.0
AU - Chen, Jia Hung
AU - Hong, Chien Tai
AU - Wu, Dean
AU - Chi, Wen Chou
AU - Yen, Chia Feng
AU - Liao, Hua Fang
AU - Chan, Lung
AU - Liou, Tsan Hon
N1 - Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Dementia is a common nonmotor condition among people with moderate or advanced Parkinson's disease (PD). Undoubtedly, profound motor symptoms cause remarkable impairment in daily activities; however, dementia-related disabilities have not been thoroughly investigated, especially not with consideration of differences according to sex. The present study used the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) to compare the functional disability between men and women with PD (PwP) with and without dementia. This study employed a registry of disability evaluation and functional assessment using the Taiwan Data Bank of Persons with Disability between July 2012 and October 2018. To investigate dementia-related disability in PwP, 1:1 matching by age and Hoehn-Yahr stage was conducted, which resulted in the inclusion of 1605 study participants in each group. The present study demonstrated that among the six major domains of WHODAS 2.0, the section of "Getting alone with others" was significantly worse in both genders of PwP with dementia; however, a greater disability in fulfilling activities of daily living was only noted in male PwP with dementia but not in their female counterparts. Neither the inability to provide self-care nor participation were significantly different between the sexes. Our findings suggested that deteriorating social relationships were a dementia-related disability in all PwP at the moderate and advanced disease stages. Regarding the performance of activities of daily living, deterioration was related to dementia only in male PwP. Such disabilities could indicate cognitive impairment in people with moderate or advanced PD and could be used as an indicator for the early detection of dementia in PwP by healthcare professionals through the easier functional assessment of the WHODAS 2.0.
AB - Dementia is a common nonmotor condition among people with moderate or advanced Parkinson's disease (PD). Undoubtedly, profound motor symptoms cause remarkable impairment in daily activities; however, dementia-related disabilities have not been thoroughly investigated, especially not with consideration of differences according to sex. The present study used the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) to compare the functional disability between men and women with PD (PwP) with and without dementia. This study employed a registry of disability evaluation and functional assessment using the Taiwan Data Bank of Persons with Disability between July 2012 and October 2018. To investigate dementia-related disability in PwP, 1:1 matching by age and Hoehn-Yahr stage was conducted, which resulted in the inclusion of 1605 study participants in each group. The present study demonstrated that among the six major domains of WHODAS 2.0, the section of "Getting alone with others" was significantly worse in both genders of PwP with dementia; however, a greater disability in fulfilling activities of daily living was only noted in male PwP with dementia but not in their female counterparts. Neither the inability to provide self-care nor participation were significantly different between the sexes. Our findings suggested that deteriorating social relationships were a dementia-related disability in all PwP at the moderate and advanced disease stages. Regarding the performance of activities of daily living, deterioration was related to dementia only in male PwP. Such disabilities could indicate cognitive impairment in people with moderate or advanced PD and could be used as an indicator for the early detection of dementia in PwP by healthcare professionals through the easier functional assessment of the WHODAS 2.0.
KW - Disability and Health (ICF)
KW - International Classification of Functioning
KW - Parkinson’s disease (PD)
KW - Parkinson’s disease dementia (PDD)
KW - World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0)
KW - Disability Evaluation
KW - World Health Organization
KW - Humans
KW - Middle Aged
KW - Disabled Persons/psychology
KW - Male
KW - Activities of Daily Living
KW - Parkinson Disease/psychology
KW - Young Adult
KW - Adolescent
KW - Sex Factors
KW - Adult
KW - Female
KW - Aged
KW - Interpersonal Relations
KW - Self Care
KW - Dementia/psychology
UR - http://www.scopus.com/inward/record.url?scp=85068831875&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85068831875&partnerID=8YFLogxK
U2 - 10.3390/ijerph16122230
DO - 10.3390/ijerph16122230
M3 - Article
C2 - 31238603
AN - SCOPUS:85068831875
SN - 1661-7827
VL - 16
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
IS - 12
M1 - 2230
ER -