摘要
The low-frequency (<0.1 Hz) fluctuation in sustained attention attracts enormous interest in cognitive neuroscience and clinical research since it always leads to cognitive and behavioral lapses. What is the source of the spontaneous fluctuation in sustained attention in neural activity, and how does the neural fluctuation relate to behavioral fluctuation? Here, we address these questions by collecting and analyzing two independent fMRI and behavior datasets. We show that the neural (fMRI) fluctuation in a key brain network, the default-mode network (DMN), mediate behavioral (reaction time) fluctuation during sustained attention. DMN shows the increased amplitude of fluctuation, which correlates with the behavioral fluctuation in a similar frequency range (0.01–0.1 Hz) but not in the lower (<0.01 Hz) or higher (>0.1 Hz) frequency range. This was observed during both auditory and visual sustained attention and was replicable across independent datasets. These results provide a novel insight into the neural source of attention-fluctuation and extend the former concept that DMN was deactivated in cognitive tasks. More generally, our findings highlight the temporal dynamic of the brain–behavior relationship.
原文 | 英語 |
---|---|
頁(從 - 到) | 5478-5489 |
頁數 | 12 |
期刊 | Human Brain Mapping |
卷 | 43 |
發行號 | 18 |
DOIs | |
出版狀態 | 接受/付印 - 2022 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 解剖學
- 放射與超音波技術
- 放射學、核子醫學和影像學
- 神經內科
- 神經病學(臨床)