Cytotoxicity and antimicrobial effects of a new fast-set MTA

Michelle Shin, Jung Wei Chen, Chi Yang Tsai, Raydolfo Aprecio, Wu Zhang, Ji Min Yochim, Naichia Teng, Mahmoud Torabinejad

研究成果: 雜誌貢獻文章同行評審

11 引文 斯高帕斯(Scopus)


Purpose. To compare the biocompatibility and antimicrobial effectiveness of the new Fast-Set MTA (FS-MTA) with ProRoot MTA (RS-MTA). Methods. The agar overlay method with neutral red dye was used. L929 mouse fibroblast cells were cultured. The liquid and oil extracts and solid test material were placed on the agar overlay, four samples for each material. Phenol was used as the positive control and cottonseed oil and MEM extracts were used as negative controls. Cytotoxicity was examined by measuring the zones of decolorization and evaluating cell lysis under an inverted microscope using the established criteria after 24 and 48 hours. The antimicrobial test was performed using the Kirby-Bauer disk-diffusion method against S. mutans, E. faecalis, F. nucleatum, P. gingivalis, and P. intermedia. The size of the zone of inhibition was measured in millimeters. Results. There was no zone of decolorization seen under or around the test materials for FS-MTA and RS-MTA at 24 and 48 hours. The antimicrobial test demonstrated no inhibitory effect of FS-MTA or RS-MTA on any bacterial species after 24 and 48 hours. Conclusions. There was no cytotoxicity or bacterial inhibition observed by the new Fast-Set MTA when compared to the ProRoot MTA after setting.
期刊BioMed Research International
出版狀態已發佈 - 2017

ASJC Scopus subject areas

  • 免疫學與微生物學 (全部)
  • 生物化學、遺傳與分子生物學 (全部)


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