Cytotoxic steroidal saponins from Agave sisalana

Pi Yu Chen; Chin Hui Chen; Ching Chuan Kuo; Zong-Huei Li; Yueh Hsiung Kuo; Ching Kuo Lee

doi:10.1055/s-0030-1250672

Cytotoxic steroidal saponins from Agave sisalana

Pi Yu Chen, Chin Hui Chen, Ching Chuan Kuo, Zong-Huei Li, Yueh Hsiung Kuo, Ching Kuo Lee

研究成果: 雜誌貢獻 › 文章 › 同行評審

38 引文斯高帕斯（Scopus）

摘要

Two new steroidal saponins, 8 and 10, along with 7 known steroidal sapogenins and saponins (1-7) and a furostanol saponin (9) were isolated from Agave sisalana Perrine ex Engelm. The structures of these two new compounds were identified and characterized by 1D and 2D NMR spectroscopy and mass spectrometry. In addition, acid hydrolysis and GC-FID were used to confirm the sugar moieties of 8 and 10. The cytotoxic effects of 1-10 on MCF-7, NCI-H460, and SF-268 cancer cells were evaluated, and among them, compound 10 proved to be the most cytotoxic with IC₅₀ values of 1.2, 3.8, and 1.5 μM, respectively.

原文	英語
頁（從 - 到）	929-933
頁數	5
期刊	Planta Medica
卷	77
發行號	9
DOIs	https://doi.org/10.1055/s-0030-1250672
出版狀態	已發佈 - 2011

ASJC Scopus subject areas

補充和替代醫學
分子醫學
有機化學
分析化學
藥學科學
藥理
藥物發現

UN SDG

此研究成果有助於以下永續發展目標

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10.1055/s-0030-1250672

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引用此

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title = "Cytotoxic steroidal saponins from Agave sisalana",

abstract = "Two new steroidal saponins, 8 and 10, along with 7 known steroidal sapogenins and saponins (1-7) and a furostanol saponin (9) were isolated from Agave sisalana Perrine ex Engelm. The structures of these two new compounds were identified and characterized by 1D and 2D NMR spectroscopy and mass spectrometry. In addition, acid hydrolysis and GC-FID were used to confirm the sugar moieties of 8 and 10. The cytotoxic effects of 1-10 on MCF-7, NCI-H460, and SF-268 cancer cells were evaluated, and among them, compound 10 proved to be the most cytotoxic with IC50 values of 1.2, 3.8, and 1.5 μM, respectively.",

keywords = "Agavaceae, Agave sisalana, MCF-7 cells, NCI-H460 cells, SF-268 cells, steroidal saponin",

author = "Chen, {Pi Yu} and Chen, {Chin Hui} and Kuo, {Ching Chuan} and Zong-Huei Li and Kuo, {Yueh Hsiung} and Lee, {Ching Kuo}",

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TY - JOUR

T1 - Cytotoxic steroidal saponins from Agave sisalana

AU - Chen, Pi Yu

AU - Chen, Chin Hui

AU - Kuo, Ching Chuan

AU - Li, Zong-Huei

AU - Kuo, Yueh Hsiung

AU - Lee, Ching Kuo

PY - 2011

Y1 - 2011

N2 - Two new steroidal saponins, 8 and 10, along with 7 known steroidal sapogenins and saponins (1-7) and a furostanol saponin (9) were isolated from Agave sisalana Perrine ex Engelm. The structures of these two new compounds were identified and characterized by 1D and 2D NMR spectroscopy and mass spectrometry. In addition, acid hydrolysis and GC-FID were used to confirm the sugar moieties of 8 and 10. The cytotoxic effects of 1-10 on MCF-7, NCI-H460, and SF-268 cancer cells were evaluated, and among them, compound 10 proved to be the most cytotoxic with IC50 values of 1.2, 3.8, and 1.5 μM, respectively.

AB - Two new steroidal saponins, 8 and 10, along with 7 known steroidal sapogenins and saponins (1-7) and a furostanol saponin (9) were isolated from Agave sisalana Perrine ex Engelm. The structures of these two new compounds were identified and characterized by 1D and 2D NMR spectroscopy and mass spectrometry. In addition, acid hydrolysis and GC-FID were used to confirm the sugar moieties of 8 and 10. The cytotoxic effects of 1-10 on MCF-7, NCI-H460, and SF-268 cancer cells were evaluated, and among them, compound 10 proved to be the most cytotoxic with IC50 values of 1.2, 3.8, and 1.5 μM, respectively.

KW - Agavaceae

KW - Agave sisalana

KW - MCF-7 cells

KW - NCI-H460 cells

KW - SF-268 cells

KW - steroidal saponin

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Cytotoxic steroidal saponins from Agave sisalana

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ASJC Scopus subject areas

UN SDG

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