Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var. formosana

Shih Chang Chien; Jang Yang Chang; Ching Chuan Kuo; Cheng Chih Hsieh; Ning Sun Yang; Yueh Hsiung Kuo

doi:10.1016/j.tetlet.2007.01.011

Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var. formosana

Shih Chang Chien, Jang Yang Chang, Ching Chuan Kuo, Cheng Chih Hsieh, Ning Sun Yang, Yueh Hsiung Kuo

研究成果: 雜誌貢獻 › 文章 › 同行評審

30 引文斯高帕斯（Scopus）

摘要

The novel skeleton compounds, chamaecypanone C (3) and obtunorlignan A (4) were isolated from the heartwood of Chamaecyparis obtusa var. formosana. The structure of 3 was elucidated as a dimeric of monoterpene and norlignan with tricyclo[5.2.2.02.6]undecane and the structure of 4 was elucidated as a norlignan skeleton by spectroscopic methods. Compound 3 exhibits potent cytotoxic activity against several human cancer cells with IC50 values ranging from 0.19 to 0.52 μM, whereas 4 has no activity.

原文	英語
頁（從 - 到）	1567-1569
頁數	3
期刊	Tetrahedron Letters
卷	48
發行號	9
DOIs	https://doi.org/10.1016/j.tetlet.2007.01.011
出版狀態	已發佈 - 2月 2007
對外發佈	是

ASJC Scopus subject areas

生物化學
藥物發現
有機化學

UN SDG

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10.1016/j.tetlet.2007.01.011

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title = "Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var. formosana",

abstract = "The novel skeleton compounds, chamaecypanone C (3) and obtunorlignan A (4) were isolated from the heartwood of Chamaecyparis obtusa var. formosana. The structure of 3 was elucidated as a dimeric of monoterpene and norlignan with tricyclo[5.2.2.02.6]undecane and the structure of 4 was elucidated as a norlignan skeleton by spectroscopic methods. Compound 3 exhibits potent cytotoxic activity against several human cancer cells with IC50 values ranging from 0.19 to 0.52 μM, whereas 4 has no activity.",

keywords = "Chamaecyparis obtusa var. formosana, Dimer of monoterpene and norlignan, Norlignan",

author = "Chien, {Shih Chang} and Chang, {Jang Yang} and Kuo, {Ching Chuan} and Hsieh, {Cheng Chih} and Yang, {Ning Sun} and Kuo, {Yueh Hsiung}",

note = "Funding Information: The authors thank the National Science Council of the Republic of China, for financial support. ",

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doi = "10.1016/j.tetlet.2007.01.011",

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AU - Chien, Shih Chang

AU - Chang, Jang Yang

AU - Kuo, Ching Chuan

AU - Hsieh, Cheng Chih

AU - Yang, Ning Sun

AU - Kuo, Yueh Hsiung

N1 - Funding Information: The authors thank the National Science Council of the Republic of China, for financial support.

PY - 2007/2

Y1 - 2007/2

N2 - The novel skeleton compounds, chamaecypanone C (3) and obtunorlignan A (4) were isolated from the heartwood of Chamaecyparis obtusa var. formosana. The structure of 3 was elucidated as a dimeric of monoterpene and norlignan with tricyclo[5.2.2.02.6]undecane and the structure of 4 was elucidated as a norlignan skeleton by spectroscopic methods. Compound 3 exhibits potent cytotoxic activity against several human cancer cells with IC50 values ranging from 0.19 to 0.52 μM, whereas 4 has no activity.

AB - The novel skeleton compounds, chamaecypanone C (3) and obtunorlignan A (4) were isolated from the heartwood of Chamaecyparis obtusa var. formosana. The structure of 3 was elucidated as a dimeric of monoterpene and norlignan with tricyclo[5.2.2.02.6]undecane and the structure of 4 was elucidated as a norlignan skeleton by spectroscopic methods. Compound 3 exhibits potent cytotoxic activity against several human cancer cells with IC50 values ranging from 0.19 to 0.52 μM, whereas 4 has no activity.

KW - Chamaecyparis obtusa var. formosana

KW - Dimer of monoterpene and norlignan

KW - Norlignan

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Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var. formosana

摘要

ASJC Scopus subject areas

UN SDG

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