Cushings disease in children: Report of three cases

Ping Yi Hsu, Yi Ching Tung, Cheng Ting Lee, Fu Sung Lo, Mu Zon Wu, Wen Yu Tsai, Yong Kwang Tu

研究成果: 雜誌貢獻文章同行評審

4 引文 斯高帕斯(Scopus)


Cushings disease is rare in children and adolescents. We report the clinical presentations of three children with Cushings disease. All three exhibited the typical symptoms and signs of weight gain and growth retardation. Tw o also demonstrated personality changes, hypertension and hypokalemia, the last of these being rarely reported in patients with Cushings disease. Lack of diurnal changes in serum cortisol levels was the most common biochemical finding. Serum cortisol levels were suppressed by low-dose dexamethasone in one patient, which is not typical for patients with Cushings disease. Imaging studies are essential for localizing the tumor. Transsphenoidal surgery remains the treatment of choice, and pituitary irradiation should be considered for those patients whose tumors cannot be totally removed. Careful follow-up of these patients with awareness of the possibilities of relapse and the complications of hypopituitarism is indicated.
頁(從 - 到)303-307
期刊Pediatrics and Neonatology
出版狀態已發佈 - 10月 1 2010

ASJC Scopus subject areas

  • 兒科、圍產兒和兒童健康


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