Crystal structures and computer screened inhibitors of Helicobacter pylori undecaprenyl pyrophosphate synthase

Chih Jung Kuo; Rey Ting Guo; I. Lin Lu; Hong Gi Liu; Su Ying Wu; Tzu Ping Ko; Andrew H.J. Wang; Po Huang Liang

doi:10.1109/FBIT.2007.34

Crystal structures and computer screened inhibitors of Helicobacter pylori undecaprenyl pyrophosphate synthase

Chih Jung Kuo, Rey Ting Guo, I. Lin Lu, Hong Gi Liu, Su Ying Wu, Tzu Ping Ko, Andrew H.J. Wang, Po Huang Liang

研究成果: 書貢獻/報告類型 › 會議貢獻

2 引文斯高帕斯（Scopus）

摘要

Helicobacter Pylori colonizes the human gastric epithelium and causes diseases such as gastritis, peptic ulcers, and stomach cancer. Undecaprenyl pyrophosphate synthase (UPPs), which catalyzes consecutive condensation reactions of farnesyl pyrophosphate with eight isopentenyl pyrophosphate to form lipid carrier for bacterial peptidoglycan biosynthesis, represents a potential target for developing new antibiotics. In the present study, X-ray structural analysis and computer virtual screening of inhibitors were performed for H. pylori UPPs. The 3-D structure of H. pylori UPPs was solved, with subtle variations from that of E. coli UPPs. Using the structures, two hits identified from 58,635 compounds through computer virtual screening displayed differential activities against H. pylori and E. coli UPPs.

原文	英語
主出版物標題	Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007
頁面	305-310
頁數	6
DOIs	https://doi.org/10.1109/FBIT.2007.34
出版狀態	已發佈 - 2007
對外發佈	是
事件	Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007 - Jeju Island, 韓國持續時間: 10月 11 2007 → 10月 13 2007

出版系列

名字	Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007

會議

會議	Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007
國家/地區	韓國
城市	Jeju Island
期間	10/11/07 → 10/13/07

ASJC Scopus subject areas

電腦科學應用
資訊系統

UN SDG

此研究成果有助於以下永續發展目標

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10.1109/FBIT.2007.34

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引用此

Kuo, C. J., Guo, R. T., Lu, I. L., Liu, H. G., Wu, S. Y., Ko, T. P., Wang, A. H. J., & Liang, P. H. (2007). Crystal structures and computer screened inhibitors of Helicobacter pylori undecaprenyl pyrophosphate synthase. 於 Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007 (頁 305-310). 文章 4524124 (Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007). https://doi.org/10.1109/FBIT.2007.34

Crystal structures and computer screened inhibitors of Helicobacter pylori undecaprenyl pyrophosphate synthase. / Kuo, Chih Jung; Guo, Rey Ting; Lu, I. Lin 等.
Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007. 2007. p. 305-310 4524124 (Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007).

研究成果: 書貢獻/報告類型 › 會議貢獻

Kuo, CJ, Guo, RT, Lu, IL, Liu, HG, Wu, SY, Ko, TP, Wang, AHJ & Liang, PH 2007, Crystal structures and computer screened inhibitors of Helicobacter pylori undecaprenyl pyrophosphate synthase. 於 Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007., 4524124, Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007, 頁 305-310, Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007, Jeju Island, 韓國, 10/11/07. https://doi.org/10.1109/FBIT.2007.34

Kuo CJ, Guo RT, Lu IL, Liu HG, Wu SY, Ko TP 等. Crystal structures and computer screened inhibitors of Helicobacter pylori undecaprenyl pyrophosphate synthase. 於 Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007. 2007. p. 305-310. 4524124. (Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007). doi: 10.1109/FBIT.2007.34

Kuo, Chih Jung ; Guo, Rey Ting ; Lu, I. Lin 等. / Crystal structures and computer screened inhibitors of Helicobacter pylori undecaprenyl pyrophosphate synthase. Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007. 2007. 頁 305-310 (Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007).

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title = "Crystal structures and computer screened inhibitors of Helicobacter pylori undecaprenyl pyrophosphate synthase",

abstract = "Helicobacter Pylori colonizes the human gastric epithelium and causes diseases such as gastritis, peptic ulcers, and stomach cancer. Undecaprenyl pyrophosphate synthase (UPPs), which catalyzes consecutive condensation reactions of farnesyl pyrophosphate with eight isopentenyl pyrophosphate to form lipid carrier for bacterial peptidoglycan biosynthesis, represents a potential target for developing new antibiotics. In the present study, X-ray structural analysis and computer virtual screening of inhibitors were performed for H. pylori UPPs. The 3-D structure of H. pylori UPPs was solved, with subtle variations from that of E. coli UPPs. Using the structures, two hits identified from 58,635 compounds through computer virtual screening displayed differential activities against H. pylori and E. coli UPPs.",

author = "Kuo, {Chih Jung} and Guo, {Rey Ting} and Lu, {I. Lin} and Liu, {Hong Gi} and Wu, {Su Ying} and Ko, {Tzu Ping} and Wang, {Andrew H.J.} and Liang, {Po Huang}",

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note = "Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007 ; Conference date: 11-10-2007 Through 13-10-2007",

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T1 - Crystal structures and computer screened inhibitors of Helicobacter pylori undecaprenyl pyrophosphate synthase

AU - Kuo, Chih Jung

AU - Guo, Rey Ting

AU - Lu, I. Lin

AU - Liu, Hong Gi

AU - Wu, Su Ying

AU - Ko, Tzu Ping

AU - Wang, Andrew H.J.

AU - Liang, Po Huang

PY - 2007

Y1 - 2007

N2 - Helicobacter Pylori colonizes the human gastric epithelium and causes diseases such as gastritis, peptic ulcers, and stomach cancer. Undecaprenyl pyrophosphate synthase (UPPs), which catalyzes consecutive condensation reactions of farnesyl pyrophosphate with eight isopentenyl pyrophosphate to form lipid carrier for bacterial peptidoglycan biosynthesis, represents a potential target for developing new antibiotics. In the present study, X-ray structural analysis and computer virtual screening of inhibitors were performed for H. pylori UPPs. The 3-D structure of H. pylori UPPs was solved, with subtle variations from that of E. coli UPPs. Using the structures, two hits identified from 58,635 compounds through computer virtual screening displayed differential activities against H. pylori and E. coli UPPs.

AB - Helicobacter Pylori colonizes the human gastric epithelium and causes diseases such as gastritis, peptic ulcers, and stomach cancer. Undecaprenyl pyrophosphate synthase (UPPs), which catalyzes consecutive condensation reactions of farnesyl pyrophosphate with eight isopentenyl pyrophosphate to form lipid carrier for bacterial peptidoglycan biosynthesis, represents a potential target for developing new antibiotics. In the present study, X-ray structural analysis and computer virtual screening of inhibitors were performed for H. pylori UPPs. The 3-D structure of H. pylori UPPs was solved, with subtle variations from that of E. coli UPPs. Using the structures, two hits identified from 58,635 compounds through computer virtual screening displayed differential activities against H. pylori and E. coli UPPs.

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T3 - Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007

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BT - Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007

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Y2 - 11 October 2007 through 13 October 2007

ER -

Crystal structures and computer screened inhibitors of Helicobacter pylori undecaprenyl pyrophosphate synthase

摘要

出版系列

會議

ASJC Scopus subject areas

UN SDG

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