TY - JOUR
T1 - Crystal structure of a z-dna fragment containing thymine/2-aminoadenine base pairs
AU - Coll, Miguel
AU - Wang, Andrew H.J.
AU - Van Der Marel, Gijs A.
AU - Van Boom, Jacques H.
AU - Rich, Alexander
PY - 1986/10
Y1 - 1986/10
N2 - The Z-DNA structure has been shown to form in two crystals made from self-complementary DNA hexamers d(CGTDCG) and d(CDCGTG) which contain thymine/2-aminoadenine (TD) base pairs. The latter structure has been solved and refined to 1.3 Å resolution and it shows only small conformational changes due to the introduction of the TD base pairs in comparison with the structure of d(CG)3. Spectroscopic studies with these compounds demonstrate that DNA molecules containing 2-aminoadenine residues form Z-DNA slightly more easily than do those containing adenine nucleotides, but not as readily as the parent sequence containing only guanine-cytosine base pairs.
AB - The Z-DNA structure has been shown to form in two crystals made from self-complementary DNA hexamers d(CGTDCG) and d(CDCGTG) which contain thymine/2-aminoadenine (TD) base pairs. The latter structure has been solved and refined to 1.3 Å resolution and it shows only small conformational changes due to the introduction of the TD base pairs in comparison with the structure of d(CG)3. Spectroscopic studies with these compounds demonstrate that DNA molecules containing 2-aminoadenine residues form Z-DNA slightly more easily than do those containing adenine nucleotides, but not as readily as the parent sequence containing only guanine-cytosine base pairs.
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U2 - 10.1080/07391102.1986.10506337
DO - 10.1080/07391102.1986.10506337
M3 - Article
C2 - 3271437
AN - SCOPUS:0022974081
SN - 0739-1102
VL - 4
SP - 157
EP - 172
JO - Journal of Biomolecular Structure and Dynamics
JF - Journal of Biomolecular Structure and Dynamics
IS - 2
ER -