TY - JOUR
T1 - CREB and leukemogenesis
AU - Cho, Er Chieh
AU - Mitton, Bryan
AU - Sakamoto, Kathleen M.
PY - 2011
Y1 - 2011
N2 - Acute myeloid leukemia (AML) is one of the most common leukemias with a 20% 5-year event-free survival in adults and 50% overall survival in children, despite aggressive chemotherapy treatment and bone marrow transplantation. The incidence and mortality rates for acute leukemia have only slightly decreased over the last 20 years, and therefore greater understanding of the molecular mechanisms associated with leukemic progression is needed. To this end, a number of transcription factors that appear to play a central role in leukemogenesis are being investigated; among them is the cAMP response element binding protein (CREB). CREB is a transcription factor that can regulate downstream targets involving in various cellular functions including cell proliferation, survival, and differentiation. In several studies, the majority of bone marrow samples from patients with acute lymphoid and myeloid leukemia demonstrate CREB overexpression. Moreover, CREB overexpression is associated with a poor outcome in AML patients. This review summarizes the role of CREB in leukemogenesis.
AB - Acute myeloid leukemia (AML) is one of the most common leukemias with a 20% 5-year event-free survival in adults and 50% overall survival in children, despite aggressive chemotherapy treatment and bone marrow transplantation. The incidence and mortality rates for acute leukemia have only slightly decreased over the last 20 years, and therefore greater understanding of the molecular mechanisms associated with leukemic progression is needed. To this end, a number of transcription factors that appear to play a central role in leukemogenesis are being investigated; among them is the cAMP response element binding protein (CREB). CREB is a transcription factor that can regulate downstream targets involving in various cellular functions including cell proliferation, survival, and differentiation. In several studies, the majority of bone marrow samples from patients with acute lymphoid and myeloid leukemia demonstrate CREB overexpression. Moreover, CREB overexpression is associated with a poor outcome in AML patients. This review summarizes the role of CREB in leukemogenesis.
KW - CREB
KW - Leukemia
KW - Oncogenesis
KW - Transcription factors
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U2 - 10.1615/CritRevOncog.v16.i1-2.50
DO - 10.1615/CritRevOncog.v16.i1-2.50
M3 - Review article
C2 - 22150306
AN - SCOPUS:83255186432
SN - 0893-9675
VL - 16
SP - 37
EP - 46
JO - Critical Reviews in Oncogenesis
JF - Critical Reviews in Oncogenesis
IS - 1-2
ER -