@article{aa70c5bd9c354fe19249c91a8e4c66fa,
title = "Coupling dichloroacetate treatment with curcumin significantly enhances anticancer potential",
abstract = "Background/Aim: Dichloroacetate (DCA) and curcumin have been shown to be potent drug candidates in cancer therapy. Our study aimed to investigate the combined effects of DCA and essential oil-blended curcumin (ECUR) using the hepatoma Huh-7 cell model. Materials and Methods: Muse{\texttrademark} Cell Cycle assay, Muse{\texttrademark} Annexin V & Dead Cell assay, Muse{\texttrademark} Oxidative Stress assay, and western blot analysis were applied to explore the underlying mechanisms. Results: DCA combined with ECUR dramatically augmented inhibition of cell survival and enhanced apoptotic induction. The enhanced apoptosis was accompanied by mitochondria-dependent apoptotic signaling activation and corroborated with significant cellular morphological alternations. Conclusion: Apoptosis was the major event contributing to the synergistically boosted antiproliferative effect. Coupling DCA treatment with curcumin may rationally be expected to lower the DCA dose needed and relatively reduce accompanying toxicity and oxidative damage while enhancing anticancer potential. This novel 'add-on' approach is, thus, of enormous value to the current DCA therapy.",
keywords = "Combination therapy, Curcumin, Dichloroacetate",
author = "Kan, {Ping Chuan} and Chang, {Yu Jia} and Chien, {Chin Sung} and Su, {Chen Ying} and Fang, {Hsu Wei}",
note = "Funding Information: 1Graduate Institute of Biochemical and Biomedical Engineering, National Taipei University of Technology, Taipei, Taiwan, R.O.C.; 2Division of General Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei, Taiwan, R.O.C.; 3Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, R.O.C.; 4Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, R.O.C.; 5Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, Taiwan, R.O.C.; 6Institute of Biomedical Engineering and Nanomedicine Research, National Health Research Institutes (NHRI), Miaoli, Taiwan, R.O.C. Publisher Copyright: {\textcopyright} 2018 International Institute of Anticancer Research.All right reserved.",
year = "2018",
month = nov,
day = "1",
doi = "10.21873/anticanres.12981",
language = "English",
volume = "38",
pages = "6253--6261",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "11",
}
