Correlation between joint [F-18] FDG PET uptake and synovial TNF-α concentration: A study with two rabbit models of acute inflammatory arthritis

Po Wei Lin; Ren Shyan Liu; Tsan Hon Liou; Li Chern Pan; Chi-Hsien Chen

doi:10.1016/j.apradiso.2007.06.006

Correlation between joint [F-18] FDG PET uptake and synovial TNF-α concentration: A study with two rabbit models of acute inflammatory arthritis

Po Wei Lin, Ren Shyan Liu, Tsan Hon Liou, Li Chern Pan, Chi-Hsien Chen

研究成果: 雜誌貢獻 › 文章 › 同行評審

10 引文斯高帕斯（Scopus）

摘要

The objective of this study was to verify that the [F-18]FDG PET synovial uptake is correlated with the synovial fluid (SF) TNF-α concentration. Two rabbit models of acute inflammatory arthritis induced by human interleukin-8 and lipopolysaccharide were used. Modified standard uptake values (MSUVs) obtained from PET images of the animals were compared with results of SF TNF-α measurements. Statistically significant correlations were found between the MSUVs and the SF TNF-α ratios. An equation to estimate the TNF-α ratio from a MSUV was also derived.

原文	英語
頁（從 - 到）	1221-1226
頁數	6
期刊	Applied Radiation and Isotopes
卷	65
發行號	11
DOIs	https://doi.org/10.1016/j.apradiso.2007.06.006
出版狀態	已發佈 - 11月 2007

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10.1016/j.apradiso.2007.06.006

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title = "Correlation between joint [F-18] FDG PET uptake and synovial TNF-α concentration: A study with two rabbit models of acute inflammatory arthritis",

abstract = "The objective of this study was to verify that the [F-18]FDG PET synovial uptake is correlated with the synovial fluid (SF) TNF-α concentration. Two rabbit models of acute inflammatory arthritis induced by human interleukin-8 and lipopolysaccharide were used. Modified standard uptake values (MSUVs) obtained from PET images of the animals were compared with results of SF TNF-α measurements. Statistically significant correlations were found between the MSUVs and the SF TNF-α ratios. An equation to estimate the TNF-α ratio from a MSUV was also derived.",

keywords = "Arthritis severity, Inflammatory arthritis, Positron emission tomography, Tumor necrosis factor alpha, [F]-fluoro-2-deoxyglucose",

author = "Lin, {Po Wei} and Liu, {Ren Shyan} and Liou, {Tsan Hon} and Pan, {Li Chern} and Chi-Hsien Chen",

year = "2007",

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doi = "10.1016/j.apradiso.2007.06.006",

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T2 - A study with two rabbit models of acute inflammatory arthritis

AU - Lin, Po Wei

AU - Liu, Ren Shyan

AU - Liou, Tsan Hon

AU - Pan, Li Chern

AU - Chen, Chi-Hsien

PY - 2007/11

Y1 - 2007/11

N2 - The objective of this study was to verify that the [F-18]FDG PET synovial uptake is correlated with the synovial fluid (SF) TNF-α concentration. Two rabbit models of acute inflammatory arthritis induced by human interleukin-8 and lipopolysaccharide were used. Modified standard uptake values (MSUVs) obtained from PET images of the animals were compared with results of SF TNF-α measurements. Statistically significant correlations were found between the MSUVs and the SF TNF-α ratios. An equation to estimate the TNF-α ratio from a MSUV was also derived.

AB - The objective of this study was to verify that the [F-18]FDG PET synovial uptake is correlated with the synovial fluid (SF) TNF-α concentration. Two rabbit models of acute inflammatory arthritis induced by human interleukin-8 and lipopolysaccharide were used. Modified standard uptake values (MSUVs) obtained from PET images of the animals were compared with results of SF TNF-α measurements. Statistically significant correlations were found between the MSUVs and the SF TNF-α ratios. An equation to estimate the TNF-α ratio from a MSUV was also derived.

KW - Arthritis severity

KW - Inflammatory arthritis

KW - Positron emission tomography

KW - Tumor necrosis factor alpha

KW - [F]-fluoro-2-deoxyglucose

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Correlation between joint [F-18] FDG PET uptake and synovial TNF-α concentration: A study with two rabbit models of acute inflammatory arthritis

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