Correlation Between Changes in Syphilis Treatment and Jarisch-Herxheimer Reaction

Young Min Yang, Katsumi Shigemura, Reo Onishi, Koki Maeda, Shian Ying Sung, Kuan Chou Chen, Soichi Arakawa, Masato Fujisawa

研究成果: 雜誌貢獻文章同行評審


The number of syphilis patients has significantly increased recently in Japan and worldwide. Previous reports, even in large institutions, may not accurately reflect the current situation in urological clinics. We therefore collected data from 11 urological clinics in Hyogo Prefecture, Japan over a 2-year period subdivided into 1) August 2016 to July 2017 and 2) August 2017 to July 2018 to compare changes in syphilis consults. We analyzed the patient data including a rapid plasma reagin test (RPR), Treponema pallidum (TP) antibody, clinical stage, therapy, and presence of Jarisch-Herxheimer reaction. In total, 45 patients presented for a first consultation, 22 in the first year and 23 in the second year. Almost all patients were male. Initial consolidation and hard chancre were the major symptoms. RPR values and TP antibody values did not change. The treatment period with amoxicillin was significantly longer in the first year (p=0.006). A Jarisch-Herxheimer reaction was seen in 13.6% in the first year and 60.9% in the second year (p=0.001). The duration of antibiotic treatments was more likely to be based on the guidelines for antibiotic use in the second year, but Jarisch-Herxheimer reactions increased. Further follow-up including recurrent patients is necessary to draw definitive conclusions.
頁(從 - 到)E137-E142
期刊Kobe Journal of Medical Sciences
出版狀態已發佈 - 2021

ASJC Scopus subject areas

  • 醫藥 (全部)


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