@article{620525941185435fa6c472ec4b623eaf,
title = "Correction of malignant behavior of tumor cells by traditional Chinese herb medicine through a restoration of p53",
abstract = "We have previously demonstrated that a UVC-induced tumorigenic HeLa x skin fibroblast cell line could be induced to form a more normal phenotypic state ('reversion'), including loss of IAP expression. We have now used the loss of IAP expression to monitor the enhancement of this reversion in the cervical cancer cell line, HeLa, by a traditional Chinese herb medicine (TCM), Yigan Kang (YGK). IAP level decreased, and the reversion frequency increased, in a dose-dependent manner at concentrations of YGK of more than 10 mg. YGK significantly repressed E6/E7 oncogenes at the transcriptional level, with subsequent reactivation of p53 and p21 expression (P",
keywords = "Cancer reversion, HPV, IAP, TCM, Yigan Kang, p53",
author = "Deng, {Win Ping} and Chao, {Ming Wei} and Wen-FuThomas Lai and Chi Sun and Chung, {Chen Yen} and Wu, {Cheng Chia} and Lin, {I. Hsin} and Hwang, {Jeng Jong} and Wu, {Chih Hsiung} and Chiu, {Wen Ta} and Chen, {Chia Yu} and Redpath, {John Leslie}",
note = "Funding Information: This study was supported by grant from the Committee on Chinese Medicine and Pharmacy, Department of Health, Taiwan, ROC (CCMP94-RD-023), and the Department of Chinese Medicine, Chung Gung Memorial Hospital, Chung-Gung University.",
year = "2006",
month = feb,
day = "28",
doi = "10.1016/j.canlet.2005.03.031",
language = "English",
volume = "233",
pages = "315--327",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "2",
}
