Constituents in purple sweet potato leaves inhibit in vitro angiogenesis with opposite effects ex vivo

Chiao-Ming Chen, Sing Chung Li, C. Y Oliver Chen, Heng Kien Au, Chun Kuang Shih, Ching Yun Hsu, Jen-Fang Liu

研究成果: 雜誌貢獻文章同行評審

16 引文 斯高帕斯(Scopus)


Objective: The aim of this study was to investigate the in vitro effect of polyphenols in purple sweet potato leaves (PSPLs) on angiogenesis in human umbilical vascular endothelial cells (HUVECs). The ex vivo effect was test in human serum collected from the subjects who consumed 200 g of PSPL in a low polyphenol diet versus a low polyphenol diet. Methods: Methanolic extract from PSPLs and human sera from subjects were treated with HUVECs and the effects of cell proliferation, migration, tube formation, and matrix metalloproteinase activity were investigated. Results: The PSPL polyphenols at 0.2 to 0.6 mM gallic acid equivalents inhibited proliferation, migration, and tube formation of vascular endothelial growth factor-treated HUVECs. Further, the activity of secreted matrix metalloproteinase-2 was decreased by at least 13.8%. However, 5% PSPL serum increased migration and tube formation of HUVECs by 110% and 56.9%, respectively, compared with serum from subjects on the low polyphenol diet. Further, the activity of matrix metalloproteinase-9 was increased by 128% in the PSPL serum. Conclusion: These results suggest that PSPL polyphenols inhibited in vitro angiogenesis, but PSPL constituents might shift serum biochemistries to be more proangiogenic.

頁(從 - 到)1177-1182
出版狀態已發佈 - 11月 2011

ASJC Scopus subject areas

  • 內分泌學、糖尿病和代謝
  • 營養與營養學


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