Consistency of complex fractionated atrial electrograms during atrial fibrillation

Yenn Jiang Lin, Ching Tai Tai, Tsair Kao, Shih Lin Chang, Wanwarang Wongcharoen, Li Wei Lo, Ta Chuan Tuan, Ameya R. Udyavar, Yi Jen Chen, Satoshi Higa, Kuo Chang Ueng, Shih Ann Chen

研究成果: 雜誌貢獻文章同行評審

110 引文 斯高帕斯(Scopus)


Background: Temporal variation in complex fractionated atrial electrograms (CFAEs) exists during atrial fibrillation (AF). Objective: This study sought to quantify the variation in CFAEs using a fractionation interval (FI) algorithm and to define the shortest optimal recording duration required to consistently characterize the magnitude of the fractionation. Methods: Twenty-seven patients undergoing AF mapping in the left atrium were studied. The FI and frequency analysis were performed at each mapped site for recording durations of 1 to 8 seconds. The magnitude of the fractionation was quantified by the FI algorithm, which calculated the mean interval between multiple, discrete deflections during AF. The results from each duration were statistically compared with the maximal-duration recording, as a standard. The FI values were compared with the dominant frequency values obtained from the associated frequency spectra. Results: The FIs obtained from recording durations between 5 and 8 seconds had a smaller variation in the FI (P < .05) and, for those sites with a FI < 50 ms, the fractionation was typically continuous. The fast-Fourier Transform spectra obtained from the CFAE sites with recording durations of >5 seconds harbored higher dominant frequency values than those with shorter recording durations (8.1 ± 2.5 Hz vs. 6.8 ± 0.98 Hz, P < .05). The CFAE sites with continuous fractionation were located within the pulmonary veins and their ostia in 77% of patients with paroxysmal AF, and in only 29% of patients with nonparoxysmal AF (P < .05). Conclusion: The assessment of fractionated electrograms requires a recording duration of ≥5 seconds at each site to obtain a consistent fractionation. Sites with the shortest FIs consistently identified sites with the fastest electrogram activity throughout the entire left atrium and pulmonary veins.

頁(從 - 到)406-412
期刊Heart Rhythm
出版狀態已發佈 - 3月 2008

ASJC Scopus subject areas

  • 心臟病學與心血管醫學
  • 生理學(醫學)


深入研究「Consistency of complex fractionated atrial electrograms during atrial fibrillation」主題。共同形成了獨特的指紋。