TY - JOUR
T1 - Concise syntheses of N-aryl-5,6,7-trimethoxyindoles as antimitotic and vascular disrupting agents
T2 - Application of the copper-mediated Ullmann-type arylation
AU - Lee, Hsueh Yun
AU - Chang, Jang-Yang
AU - Chang, Ling-Yin
AU - Lai, Wen-Yang
AU - Lai, Mei-Jung
AU - Shih, Kuang-Hsing
AU - Kuo, Ching-Chuan
AU - Chang, Chi-Yen
AU - Liou, Jing Ping
PY - 2011/5/7
Y1 - 2011/5/7
N2 - In an attempt to mimic the 3,4,5-trimethoxyphenyl-Z-stilbene moiety of combretastatin A-4, a series of N-aryl-5,6,7-trimethoxyindoles were synthesized via copper-catalyzed Ullmann-type N-arylation through the corresponding 5,6,7-trimethoxyindole and aryl halides. These synthesized compounds demonstrated potent antiproliferative activity providing a novel skeleton for potent tubulin polymerization inhibitors.
AB - In an attempt to mimic the 3,4,5-trimethoxyphenyl-Z-stilbene moiety of combretastatin A-4, a series of N-aryl-5,6,7-trimethoxyindoles were synthesized via copper-catalyzed Ullmann-type N-arylation through the corresponding 5,6,7-trimethoxyindole and aryl halides. These synthesized compounds demonstrated potent antiproliferative activity providing a novel skeleton for potent tubulin polymerization inhibitors.
UR - http://www.scopus.com/inward/record.url?scp=79954441934&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79954441934&partnerID=8YFLogxK
U2 - 10.1039/c0ob01038c
DO - 10.1039/c0ob01038c
M3 - Article
C2 - 21416070
AN - SCOPUS:79954441934
SN - 1477-0520
VL - 9
SP - 3154
EP - 3157
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
IS - 9
ER -