Complete sequences of two plasmids in a blandm-1-positive klebsiella oxytoca isolate from taiwan

Tzu Wen Huang; Jann Tay Wang; Tsai Ling Lauderdale; Tsai Lien Liao; Jui Fen Lai; Mei Chen Tan; Ann Chi Lin; Ying Tsong Chen; Shih Feng Tsai; Shan Chwen Chang

doi:10.1128/AAC.02266-12

Complete sequences of two plasmids in a blandm-1-positive klebsiella oxytoca isolate from taiwan

Tzu Wen Huang, Jann Tay Wang, Tsai Ling Lauderdale, Tsai Lien Liao, Jui Fen Lai, Mei Chen Tan, Ann Chi Lin, Ying Tsong Chen, Shih Feng Tsai, Shan Chwen Chang

研究成果: 雜誌貢獻 › 文章 › 同行評審

56 引文斯高帕斯（Scopus）

摘要

Genetic determinants of a blaNDM-1-positive, multidrug-resistant bacterial isolate that caused active infection was investigated by DNA sequencing. Two plasmids, pKOX-NDM1 and pKOX-R1, were identified for the Klebsiella oxytoca strain E718. Sequence annotation revealed a blaNDM-1 gene in pKOX-NDM1 and two extended-spectrum-lactamase producers (blaCTX-M-3 and blaSHV-12) and a wide array of resistance genes in pKOX-R1. These findings highlight the difficulty in treating multidrugresistant bacterial infections and the potential danger of emerging resistant enterobacteria.

原文	英語
頁（從 - 到）	4072-4076
頁數	5
期刊	Antimicrobial Agents and Chemotherapy
卷	57
發行號	8
DOIs	https://doi.org/10.1128/AAC.02266-12
出版狀態	已發佈 - 8月 2013
對外發佈	是

ASJC Scopus subject areas

藥學（醫學）
傳染性疾病
藥理

UN SDG

此研究成果有助於以下永續發展目標

存取文件

10.1128/AAC.02266-12

其它文件與鏈接

Link to publication in Scopus

引用此

@article{a262b2c6e77e4020ba5e49809e656600,

title = "Complete sequences of two plasmids in a blandm-1-positive klebsiella oxytoca isolate from taiwan",

abstract = "Genetic determinants of a blaNDM-1-positive, multidrug-resistant bacterial isolate that caused active infection was investigated by DNA sequencing. Two plasmids, pKOX-NDM1 and pKOX-R1, were identified for the Klebsiella oxytoca strain E718. Sequence annotation revealed a blaNDM-1 gene in pKOX-NDM1 and two extended-spectrum-lactamase producers (blaCTX-M-3 and blaSHV-12) and a wide array of resistance genes in pKOX-R1. These findings highlight the difficulty in treating multidrugresistant bacterial infections and the potential danger of emerging resistant enterobacteria.",

author = "Huang, {Tzu Wen} and Wang, {Jann Tay} and Lauderdale, {Tsai Ling} and Liao, {Tsai Lien} and Lai, {Jui Fen} and Tan, {Mei Chen} and Lin, {Ann Chi} and Chen, {Ying Tsong} and Tsai, {Shih Feng} and Chang, {Shan Chwen}",

year = "2013",

month = aug,

doi = "10.1128/AAC.02266-12",

language = "English",

volume = "57",

pages = "4072--4076",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "8",

}

TY - JOUR

T1 - Complete sequences of two plasmids in a blandm-1-positive klebsiella oxytoca isolate from taiwan

AU - Huang, Tzu Wen

AU - Wang, Jann Tay

AU - Lauderdale, Tsai Ling

AU - Liao, Tsai Lien

AU - Lai, Jui Fen

AU - Tan, Mei Chen

AU - Lin, Ann Chi

AU - Chen, Ying Tsong

AU - Tsai, Shih Feng

AU - Chang, Shan Chwen

PY - 2013/8

Y1 - 2013/8

N2 - Genetic determinants of a blaNDM-1-positive, multidrug-resistant bacterial isolate that caused active infection was investigated by DNA sequencing. Two plasmids, pKOX-NDM1 and pKOX-R1, were identified for the Klebsiella oxytoca strain E718. Sequence annotation revealed a blaNDM-1 gene in pKOX-NDM1 and two extended-spectrum-lactamase producers (blaCTX-M-3 and blaSHV-12) and a wide array of resistance genes in pKOX-R1. These findings highlight the difficulty in treating multidrugresistant bacterial infections and the potential danger of emerging resistant enterobacteria.

AB - Genetic determinants of a blaNDM-1-positive, multidrug-resistant bacterial isolate that caused active infection was investigated by DNA sequencing. Two plasmids, pKOX-NDM1 and pKOX-R1, were identified for the Klebsiella oxytoca strain E718. Sequence annotation revealed a blaNDM-1 gene in pKOX-NDM1 and two extended-spectrum-lactamase producers (blaCTX-M-3 and blaSHV-12) and a wide array of resistance genes in pKOX-R1. These findings highlight the difficulty in treating multidrugresistant bacterial infections and the potential danger of emerging resistant enterobacteria.

UR - http://www.scopus.com/inward/record.url?scp=84880272508&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880272508&partnerID=8YFLogxK

U2 - 10.1128/AAC.02266-12

DO - 10.1128/AAC.02266-12

M3 - Article

C2 - 23752513

AN - SCOPUS:84880272508

SN - 0066-4804

VL - 57

SP - 4072

EP - 4076

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 8

ER -

Complete sequences of two plasmids in a blandm-1-positive klebsiella oxytoca isolate from taiwan

摘要

ASJC Scopus subject areas

UN SDG

存取文件

其它文件與鏈接

指紋

引用此