Comparison of Intravenous and Enteral Indomethacin Administration for Closure of Patent Ductus Arteriosus in Extremely-low-birth-weight Infants

Pei Chen Tsao, Shu Jen Chen, Chia Feng Yang, Yu Sheng Lee, Mei Jy Jeng, Wen Jue Soong, Pi Chang Lee, Jen Her Lu, Betau Hwang, Ren Bin Tang

研究成果: 雜誌貢獻文章同行評審

5 引文 斯高帕斯(Scopus)

摘要

Background: The objective of this retrospective cohort study was to compare the patent ductus arteriosus (PDA) closure rate with different routes (intravenous and enteral) of indomethacin treatment and neonatal outcomes. Methods: Infants with a birthweight < 1,000 g born between July 1997 and June 2007 at Taipei Veterans General Hospital and who received indomethacin treatment for PDA were included in the study. Outcome measures were ductal closure rate and neonatal outcomes. Results: Of 41 extremely-low-birth-weight infants with PDA, 3 infants had spontaneous closure and 3 died before treatment. Of the remaining 35 infants, 13 received enteral ethanol solution of indomethacin and 22 received the intravenous (IV) form. The total closure rates of the IV and enteral groups were 81.8% and 76.9%, respectively. There were no significant differences in the incidence of impaired renal function, necrotizing enterocolitis, chronic lung disease or severe retinopathy of prematurity between the 2 groups. Conclusion: Our results suggest that ethanol-based indomethacin is an effective alternative to IV indomethacin for the pharmacological closure of PDA in extremely-low-birth-weight infants.

原文英語
頁(從 - 到)15-20
頁數6
期刊Journal of the Chinese Medical Association
73
發行號1
DOIs
出版狀態已發佈 - 1月 2010
對外發佈

ASJC Scopus subject areas

  • 醫藥 (全部)

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