Comparison Between Child-Turcotte-Pugh and Albumin-Bilirubin Scores in Assessing the Prognosis of Hepatocellular Carcinoma After Stereotactic Ablative Radiation Therapy

Cheng Hsiang Lo, Ming Yueh Liu, Meei Shyuan Lee, Jen Fu Yang, Yee Min Jen, Chun Shu Lin, Hsing Lung Chao, Po Chien Shen, Wen Yen Huang

研究成果: 雜誌貢獻文章同行評審

34 引文 斯高帕斯(Scopus)

摘要

Purpose To evaluate the prognostic performance of the Child-Turcotte-Pugh (CTP) score and the albumin-bilirubin (ALBI) score in hepatocellular carcinoma (HCC) patients treated using stereotactic ablative radiation therapy (SABR). Methods and Materials This retrospective study evaluated the data of patients with HCC who underwent SABR between December 2007 and June 2015. We collected pretreatment CTP and ALBI scores and analyzed their correlation with survival and liver toxicity. Results This study included 152 HCC patients: 78.3% of CTP class A and 21.7% of CTP class B. The median ALBI score was −2.49 (range, −3.67 to −0.84) with 39.5% of grade 1, 56.6% of grade 2, and 3.9% of grade 3. The CTP classification and ALBI grade were significantly associated with overall survival (P<.001). Albumin-bilirubin grade (1 vs 2) had a trend to stratify CTP class A patients into 2 risk groups of mortality (P=.061). Combined CTP class and ALBI score could predict development of radiation-induced liver disease (2.4% in CTP A-ALBI < −2.76, 15.1% in CTP A-ALBI ≥ −2.76, and 25.8% in CTP B). Conclusion Albumin-bilirubin score is a potential predictor for both survival and liver toxicity. Complementary use of CTP and ALBI score could predict the risk of post-SABR liver toxicity. Further prospective studies are necessary before use of the ALBI score can become part of daily practice.
原文英語
頁(從 - 到)145-152
頁數8
期刊International Journal of Radiation Oncology Biology Physics
99
發行號1
DOIs
出版狀態已發佈 - 9月 1 2017
對外發佈

ASJC Scopus subject areas

  • 輻射
  • 腫瘤科
  • 放射學、核子醫學和影像學
  • 癌症研究

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