TY - JOUR
T1 - Combination of molecular assay and clinical evaluation for early confirmation of tuberculosis cases
AU - Tu, Hui Z.
AU - Chen, Yao Shen
AU - Lin, Y. E.
AU - Tseng, M. R.
AU - Huang, Tsi S.
AU - Tsai, Hung Chin
AU - Liu, Yung-Ching
PY - 2011/5
Y1 - 2011/5
N2 - The cost-effectiveness of the ProbeTec ET Direct TB assay (DTB) was compared with that of culture for detection of Mycobacterium tuberculosis complex in 361 acid-fast stain-positive respiratory specimens. The overall sensitivity, specificity, positive predictive value and negative predictive value of DTB were 97.7%, 86.6%, 87.2% and 97.6%, respectively. When clinical evaluation was added to DTB, the specificity and positive predictive value of DTB increased to 94.7% and 95.4%, respectively. Treatment costs of $133521 would have been saved in this cohort if DTB, instead of culture results, had been used to eliminate 'false-positive' smear results.
AB - The cost-effectiveness of the ProbeTec ET Direct TB assay (DTB) was compared with that of culture for detection of Mycobacterium tuberculosis complex in 361 acid-fast stain-positive respiratory specimens. The overall sensitivity, specificity, positive predictive value and negative predictive value of DTB were 97.7%, 86.6%, 87.2% and 97.6%, respectively. When clinical evaluation was added to DTB, the specificity and positive predictive value of DTB increased to 94.7% and 95.4%, respectively. Treatment costs of $133521 would have been saved in this cohort if DTB, instead of culture results, had been used to eliminate 'false-positive' smear results.
KW - Clinical diagnosis
KW - Cost-effective diagnostic method
KW - Non-tuberculosis mycobacteria
KW - Strand displacement amplification
KW - Tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=79955408950&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955408950&partnerID=8YFLogxK
U2 - 10.1111/j.1469-0691.2010.03309.x
DO - 10.1111/j.1469-0691.2010.03309.x
M3 - Article
C2 - 20636424
AN - SCOPUS:79955408950
SN - 1198-743X
VL - 17
SP - 712
EP - 714
JO - Clinical Microbiology and Infection
JF - Clinical Microbiology and Infection
IS - 5
ER -
