@article{2fa700623e75469e81d3315a1769bd1d,
title = "Cognitive Load of Exercise Influences Cognition and Neuroplasticity of Healthy Elderly: An Exploratory Investigation",
abstract = "This study explored the effects of exercise with either high cognitive load or low cognitive load on cognitive performance and neuroplasticity in healthy elderly. Twenty-eight sedentary community-dwelling seniors participated in this study. Participants were assigned to one of three groups: the control group (C), low-cognitive load exercise group (LE), or high-cognitive load exercise group (HE). Individuals in both exercise groups engaged in moderate-intensity aerobic exercise for 4 months. Resting-state functional MRI and diffusion MRI were used to investigate the effects of intervention on functional and structural connectivity, respectively. Analysis of covariance with baseline, age and the education year as covariates was used to determine the effects of intervention. We found 4 months of exercise with high-cognitive load, but not exercise with low-cognitive load, improved the overall cognitive function of healthy elderly. Additionally, the HE group showed increased resting-state functional connectivity of superior frontal gyrus and anterior cingulate cortex and decreased functional connectivity of middle occipital gyrus and postcentral gyrus. The age-related alterations in local efficiency and betweenness were protected by exercise. Our findings might suggest that exercise with greater cognitive load likely results in greater training effects on cognition and brain connectivity than exercise requiring lower cognitive loads for healthy elderly.",
keywords = "Dance, Diffusion tensor imaging, Functional connectivity, Plasticity",
author = "Chao, {Yi Ping} and Wu, {Changwei W.} and Lin, {Li Jung} and Lai, {Cheng Hung} and Wu, {Hong Yi} and Hsu, {Ai Ling} and Chen, {Chiao Nan}",
note = "Funding Information: We thank all the subjects who volunteered to participate this study. This work was supported by Ministry of Science and Technology (MOST 104–2410-H-182–026, MOST 105–2628-B-038–013-MY3 & MOST 108–2321-B-038–005-MY2), Chang Gung Memorial Hospital (BMRPB41, BMRPC78) and National Health Research Institutes (NHRI-EX108-10829-EI). We also thank the MOST-supported Imaging Center for Integrated Body, Mind and Culture Research, National Taiwan University for technical and facility supports. This manuscript was edited by Wallace Academic Editing. Funding Information: We thank all the subjects who volunteered to participate this study. This work was supported by Ministry of Science and Technology (MOST 104–2410-H-182–026, MOST 105–2628-B-038–013-MY3 & MOST 108–2321-B-038–005-MY2), Chang Gung Memorial Hospital (BMRPB41, BMRPC78) and National Health Research Institutes (NHRI-EX108-10829-EI). We also thank the MOST-supported Imaging Center for Integrated Body, Mind and Culture Research, National Taiwan University for technical and facility supports. This manuscript was edited by Wallace Academic Editing. Publisher Copyright: {\textcopyright} 2020, The Author(s).",
year = "2020",
month = jun,
day = "1",
doi = "10.1007/s40846-020-00522-x",
language = "English",
volume = "40",
pages = "391--399",
journal = "Journal of Medical and Biological Engineering",
issn = "1609-0985",
publisher = "中華民國生物醫學工程學會",
number = "3",
}