Cognitive impairment in fibromyalgia: A meta-analysis of case-control studies

Yu Lin Wu, Chun Jen Huang, Su Chen Fang, Ling Hsin Ko, Pei Shan Tsai

研究成果: 雜誌貢獻回顧型文獻同行評審

44 引文 斯高帕斯(Scopus)


Objective Cognitive dysfunction has been reported in individuals with fibromyalgia. However, findings regarding cognitive function examined using neuropsychological tests have been inconsistent. The aim of the study was to determine domain-specific cognitive impairment in patients with fibromyalgia compared with healthy controls. Methods We conducted a meta-analysis that systematically searched six databases (PubMed, Ovid MEDLINE, Embase, CINAHL, PsycINFO, and Web of Science) for articles published before September 2017. Results Twenty-three case-control studies with a total of 2096 participants were included in the meta-analysis. Cognitive function was significantly lower (g = 0.87, 95% confidence interval [CI] = 0.60-1.15) in individuals with fibromyalgia than in healthy controls. Large effect sizes were found in learning/memory and attention/psychomotor speed (g = 0.94, p =.013; g = 1.22, p <.001, respectively); medium effect sizes were reported in executive function and working memory (g = 0.72, p <.001; g = 0.75, p <.001, respectively). Depression and anxiety scores were associated with the effect size of group differences in cognitive function (B = 0.11, p <.001, 95% CI = 0.09-0.13; B = 0.02, p <.001, 95% CI = 0.01-0.02, respectively). Conclusions Cognitive impairment across different cognitive domains was found in individuals with fibromyalgia compared with healthy controls. Mood states (depression and anxiety) may explain the heterogeneity across studies.
頁(從 - 到)432-438
期刊Psychosomatic Medicine
出版狀態已發佈 - 6月 1 2018

ASJC Scopus subject areas

  • 應用心理學
  • 精神病學和心理健康


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