TY - JOUR
T1 - Cobalamin deficiency with myelopathy
T2 - MRI findings
AU - Chien, Jerry Chin Wei
AU - Hong, Chi Tzong
AU - Chan, Wing P.
PY - 2002/12
Y1 - 2002/12
N2 - We described a 61-year-old man with cobalamin deficiency presenting with thoracic myelopathy for one month. Initial T2-weighted MR images revealed abnormal symmetrical hyperintense signal at posterior column of the spinal cord between T7 and T10 levels. The vertebral bone marrow depicted abnormal hypointense signal on both T1 and T2-weighted images. Subsequent serological test confirmed cobalamin deficiency. Although only few cases have been reported, abnormal MRI findings on the spinal cord and vertebral bone marrow should alert clinicians to consider Cobalamin deficiency. Laboratory tests should be performed to confirm the diagnosis. In our case, follow-up MRI findings correlated well with clinical outcome after treatment.
AB - We described a 61-year-old man with cobalamin deficiency presenting with thoracic myelopathy for one month. Initial T2-weighted MR images revealed abnormal symmetrical hyperintense signal at posterior column of the spinal cord between T7 and T10 levels. The vertebral bone marrow depicted abnormal hypointense signal on both T1 and T2-weighted images. Subsequent serological test confirmed cobalamin deficiency. Although only few cases have been reported, abnormal MRI findings on the spinal cord and vertebral bone marrow should alert clinicians to consider Cobalamin deficiency. Laboratory tests should be performed to confirm the diagnosis. In our case, follow-up MRI findings correlated well with clinical outcome after treatment.
KW - Anemia
KW - Bone marrow
KW - Cobalamin deficiency
KW - Magnetic resonance imaging (MRI)
KW - Spinal cord
KW - Subacute combined degeneration
KW - Vitamin B deficiency
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M3 - Article
AN - SCOPUS:0036934061
SN - 1018-8940
VL - 27
SP - 325
EP - 328
JO - Chinese Journal of Radiology
JF - Chinese Journal of Radiology
IS - 6
ER -