TY - JOUR
T1 - Coagulation Activation in Type 2 Diabetes Mellitus
T2 - the Higher Coronary Risk of Female Diabetic Patients
AU - Chan, P.
AU - Pan, W. H.
PY - 1995/6
Y1 - 1995/6
N2 - Thrombophilia in diabetic patients is a well‐recognized phenomenon which constitutes an additional risk of coronary heart disease. This study included 1980 ethnic Chinese people (835 male, 1145 female); age range: 45 to 69 years, including 280 Type 2 diabetic patients (male 125, female 155). Haemostatic parameters measured were fibrinogen, prothrombin time, activated partial thromboplastin time (APTT), factor VIIc, factor VIIIc, antithrombin III, and plasminogen. Compared with a control group, male diabetic patients showed significantly shorter APTT (25.6 ± 3.7 vs 27.5 ± 3.6 s, p<0.001), and elevated factor VIIIc (171.1 ± 77.48 vs 131.16 ± 52.23%, p<0.0001), whereas female diabetic patients showed significantly shorter APTT (24.9 ± 4.2 vs 26.5 ± 3.9 s, p<0.001) and elevated fibrinogen (10.6 ± 3.3 vs 9.8 ± 2.6 μmol 1−1, p<0.05), factor VIIc (150.4 ± 68.7 vs 135.3 ± 32.3%, p<0.001), factor VIIIc (190.1 ± 92.6 vs 141.1 ± 62.4%, p<0.0001), and plasminogen (140.3 ± 41.9 vs 128.4 ± 38.7%, p<0.01). This study showed that Chinese diabetic patients had coagulation activation, and that female diabetic patients seemed to constitute a higher risk group for coronary heart disease than males. 1995 Diabetes UK
AB - Thrombophilia in diabetic patients is a well‐recognized phenomenon which constitutes an additional risk of coronary heart disease. This study included 1980 ethnic Chinese people (835 male, 1145 female); age range: 45 to 69 years, including 280 Type 2 diabetic patients (male 125, female 155). Haemostatic parameters measured were fibrinogen, prothrombin time, activated partial thromboplastin time (APTT), factor VIIc, factor VIIIc, antithrombin III, and plasminogen. Compared with a control group, male diabetic patients showed significantly shorter APTT (25.6 ± 3.7 vs 27.5 ± 3.6 s, p<0.001), and elevated factor VIIIc (171.1 ± 77.48 vs 131.16 ± 52.23%, p<0.0001), whereas female diabetic patients showed significantly shorter APTT (24.9 ± 4.2 vs 26.5 ± 3.9 s, p<0.001) and elevated fibrinogen (10.6 ± 3.3 vs 9.8 ± 2.6 μmol 1−1, p<0.05), factor VIIc (150.4 ± 68.7 vs 135.3 ± 32.3%, p<0.001), factor VIIIc (190.1 ± 92.6 vs 141.1 ± 62.4%, p<0.0001), and plasminogen (140.3 ± 41.9 vs 128.4 ± 38.7%, p<0.01). This study showed that Chinese diabetic patients had coagulation activation, and that female diabetic patients seemed to constitute a higher risk group for coronary heart disease than males. 1995 Diabetes UK
KW - Coagulation
KW - Coronary risk factor
KW - Type 2 diabetes mellutis
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U2 - 10.1111/j.1464-5491.1995.tb00532.x
DO - 10.1111/j.1464-5491.1995.tb00532.x
M3 - Article
C2 - 7648824
AN - SCOPUS:0029030689
SN - 0742-3071
VL - 12
SP - 504
EP - 507
JO - Diabetic Medicine
JF - Diabetic Medicine
IS - 6
ER -
