TY - JOUR
T1 - Coagulation activation in Type 2 diabetes mellitus the higher coronary risk of female diabetic patients
AU - Chan, P.
AU - Pan, W. H.
PY - 1995
Y1 - 1995
N2 - Thrombophilia in diabetic patients is a well-recognized phenomenon which constitutes an additional risk of coronary heart disease. This study included 1980 ethnic Chinese people (835 male, 1145 female); age range: 45 to 69 years, including 280 Type 2 diabetic patients (male 125, female 155). Haemostatic parameters measured were fibrinogen, prothrombin time, activated partial thromboplastin time (APTT), factor VIIc, factor VIIIc, antithrombin III, and plasminogen. Compared with a control group, male diabetic patients showed significantly shorter APTT (25.6 ± 3.7 vs 27.5 ± 3.6 s, p <0.01), and elevated factor VIIIc (171.1 ± 77.48 vs 131.16 ± 52.23%, p <0.0001), whereas female diabetic patients showed significantly shorter APTT (24.9 ± 4.2 vs 26.5 ± 3.9 s, p <0.001) and elevated fibrinogen (10.6 ± 3.3 vs 9.8 ± 2.6 μmol 1-1, p
AB - Thrombophilia in diabetic patients is a well-recognized phenomenon which constitutes an additional risk of coronary heart disease. This study included 1980 ethnic Chinese people (835 male, 1145 female); age range: 45 to 69 years, including 280 Type 2 diabetic patients (male 125, female 155). Haemostatic parameters measured were fibrinogen, prothrombin time, activated partial thromboplastin time (APTT), factor VIIc, factor VIIIc, antithrombin III, and plasminogen. Compared with a control group, male diabetic patients showed significantly shorter APTT (25.6 ± 3.7 vs 27.5 ± 3.6 s, p <0.01), and elevated factor VIIIc (171.1 ± 77.48 vs 131.16 ± 52.23%, p <0.0001), whereas female diabetic patients showed significantly shorter APTT (24.9 ± 4.2 vs 26.5 ± 3.9 s, p <0.001) and elevated fibrinogen (10.6 ± 3.3 vs 9.8 ± 2.6 μmol 1-1, p
KW - Coagulation
KW - Coronary risk factor
KW - Type 2 diabetes mellitis
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M3 - Article
C2 - 7648824
AN - SCOPUS:0029030689
SN - 0742-3071
VL - 12
SP - 504
EP - 507
JO - Diabetic Medicine
JF - Diabetic Medicine
IS - 6
ER -