CMR-Derived Extracellular Volume Fraction is Associated with the Ventricular Wall Thickness in Patients with Hypertrophic Cardiomyopathy

Shun Chung Yang, Hung Wen Chiu, Mao Yuan Su

研究成果: 書貢獻/報告類型會議貢獻

摘要

Background: Hypertrophic cardiomyopathy (H- CM) is hereditary cardiomyopathy that is characterized by left ventricular hypertrophy (LVH). LVH can develop in response to some factors, such as hypertension, aortic stenosis, or diffuse myocardial fibrosis (DMF). Cardiovascular magnetic resonance (CMR) has been widely used to quantify DMF by calculating the extracellular volume fraction (ECV) of the myocardium. Our aim was to investigate whether the severity of ventricular hypertrophy is associated with the degree of DMF in patients with HCM. Materials and methods: Patients with HCM (n = 125, age 58 ± 16 yrs) and Brugada syndrome (Brs) which was considered as the relative normal heart control (n = 58, age 51 ± 14 yrs) were retrospectively enrolled in this study. Pre- and postcontrast T1 maps and Cine images were acquired at 1.5 T for the assessment of ECV and wall thickness (WT). ECV and WT measurements at 4 different regions, including the anterior, septal, posterior, and lateral wall regions, were measured, and all groups were compared. Regional ECV was correlated with the corresponding regional WT. Group comparison between two groups in ECV and WT were analyzed with the Mann–Whitney U test. Linear regression was used to obtain a correlation coefficient between regional ECV and WT. The statistical tests were two-tailed, and statistical significance was defined as p < 0.05. Results: For the group comparison, HCM patients showed a significantly higher WT compared to that in controls (11.3 ± 5.1 mm vs. 6.0 ± 2.2 mm, p < 0.001). In addition, HCM patients also revealed significantly higher ECV compared to that in controls (27.5 ± 4.9% vs. 25.0 ± 2.3%, p < 0.001). The regional ECV was significantly correlated with the corresponding regional WT in patients with HCM (r = 0.311, p < 0.001). In contrast, no significant correlation (r = 0.139, p = 0.297) was found between regional ECV and WT in controls. Conclusion: In this study, we demonstrated that HCM pa tients with higher WT compared with controls. This finding supports that HCM patients have significant LVH. The increased ECV was positively associated with the corresponding regional wall thickness. This finding suggests that the severity of LVH might be associated with the degree of DMF in patients with HCM.

原文英語
主出版物標題Future Trends and Challenges of Molecular Imaging and AI Innovation - Proceedings of FASMI 2020
編輯Kang-Ping Lin, Ren-Shyan Liu, Bang-Hung Yang
發行者Springer Science and Business Media Deutschland GmbH
頁面27-33
頁數7
ISBN(列印)9783030927851
DOIs
出版狀態已發佈 - 2022
事件International conference of Federation of Asian Societies for Molecular Imaging, FASMI 2020 - Taipei, 臺灣
持續時間: 11月 20 202011月 22 2020

出版系列

名字Springer Proceedings in Physics
272
ISSN(列印)0930-8989
ISSN(電子)1867-4941

會議

會議International conference of Federation of Asian Societies for Molecular Imaging, FASMI 2020
國家/地區臺灣
城市Taipei
期間11/20/2011/22/20

ASJC Scopus subject areas

  • 一般物理與天文學

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