TY - GEN
T1 - CMR-Derived Extracellular Volume Fraction is Associated with the Ventricular Wall Thickness in Patients with Hypertrophic Cardiomyopathy
AU - Yang, Shun Chung
AU - Chiu, Hung Wen
AU - Su, Mao Yuan
N1 - Funding Information:
I?m very grateful to my teacher, Mr. Mao-Yuan Su. He taught me a lot about MRI. He also helped me with this research project. I would like to thank Mr. Chiu for his constant encouragement and guidance.
Publisher Copyright:
© 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.
PY - 2022
Y1 - 2022
N2 - Background: Hypertrophic cardiomyopathy (H- CM) is hereditary cardiomyopathy that is characterized by left ventricular hypertrophy (LVH). LVH can develop in response to some factors, such as hypertension, aortic stenosis, or diffuse myocardial fibrosis (DMF). Cardiovascular magnetic resonance (CMR) has been widely used to quantify DMF by calculating the extracellular volume fraction (ECV) of the myocardium. Our aim was to investigate whether the severity of ventricular hypertrophy is associated with the degree of DMF in patients with HCM. Materials and methods: Patients with HCM (n = 125, age 58 ± 16 yrs) and Brugada syndrome (Brs) which was considered as the relative normal heart control (n = 58, age 51 ± 14 yrs) were retrospectively enrolled in this study. Pre- and postcontrast T1 maps and Cine images were acquired at 1.5 T for the assessment of ECV and wall thickness (WT). ECV and WT measurements at 4 different regions, including the anterior, septal, posterior, and lateral wall regions, were measured, and all groups were compared. Regional ECV was correlated with the corresponding regional WT. Group comparison between two groups in ECV and WT were analyzed with the Mann–Whitney U test. Linear regression was used to obtain a correlation coefficient between regional ECV and WT. The statistical tests were two-tailed, and statistical significance was defined as p < 0.05. Results: For the group comparison, HCM patients showed a significantly higher WT compared to that in controls (11.3 ± 5.1 mm vs. 6.0 ± 2.2 mm, p < 0.001). In addition, HCM patients also revealed significantly higher ECV compared to that in controls (27.5 ± 4.9% vs. 25.0 ± 2.3%, p < 0.001). The regional ECV was significantly correlated with the corresponding regional WT in patients with HCM (r = 0.311, p < 0.001). In contrast, no significant correlation (r = 0.139, p = 0.297) was found between regional ECV and WT in controls. Conclusion: In this study, we demonstrated that HCM pa tients with higher WT compared with controls. This finding supports that HCM patients have significant LVH. The increased ECV was positively associated with the corresponding regional wall thickness. This finding suggests that the severity of LVH might be associated with the degree of DMF in patients with HCM.
AB - Background: Hypertrophic cardiomyopathy (H- CM) is hereditary cardiomyopathy that is characterized by left ventricular hypertrophy (LVH). LVH can develop in response to some factors, such as hypertension, aortic stenosis, or diffuse myocardial fibrosis (DMF). Cardiovascular magnetic resonance (CMR) has been widely used to quantify DMF by calculating the extracellular volume fraction (ECV) of the myocardium. Our aim was to investigate whether the severity of ventricular hypertrophy is associated with the degree of DMF in patients with HCM. Materials and methods: Patients with HCM (n = 125, age 58 ± 16 yrs) and Brugada syndrome (Brs) which was considered as the relative normal heart control (n = 58, age 51 ± 14 yrs) were retrospectively enrolled in this study. Pre- and postcontrast T1 maps and Cine images were acquired at 1.5 T for the assessment of ECV and wall thickness (WT). ECV and WT measurements at 4 different regions, including the anterior, septal, posterior, and lateral wall regions, were measured, and all groups were compared. Regional ECV was correlated with the corresponding regional WT. Group comparison between two groups in ECV and WT were analyzed with the Mann–Whitney U test. Linear regression was used to obtain a correlation coefficient between regional ECV and WT. The statistical tests were two-tailed, and statistical significance was defined as p < 0.05. Results: For the group comparison, HCM patients showed a significantly higher WT compared to that in controls (11.3 ± 5.1 mm vs. 6.0 ± 2.2 mm, p < 0.001). In addition, HCM patients also revealed significantly higher ECV compared to that in controls (27.5 ± 4.9% vs. 25.0 ± 2.3%, p < 0.001). The regional ECV was significantly correlated with the corresponding regional WT in patients with HCM (r = 0.311, p < 0.001). In contrast, no significant correlation (r = 0.139, p = 0.297) was found between regional ECV and WT in controls. Conclusion: In this study, we demonstrated that HCM pa tients with higher WT compared with controls. This finding supports that HCM patients have significant LVH. The increased ECV was positively associated with the corresponding regional wall thickness. This finding suggests that the severity of LVH might be associated with the degree of DMF in patients with HCM.
KW - CMR
KW - ECV
KW - HCM
UR - http://www.scopus.com/inward/record.url?scp=85126232222&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85126232222&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-92786-8_4
DO - 10.1007/978-3-030-92786-8_4
M3 - Conference contribution
AN - SCOPUS:85126232222
SN - 9783030927851
T3 - Springer Proceedings in Physics
SP - 27
EP - 33
BT - Future Trends and Challenges of Molecular Imaging and AI Innovation - Proceedings of FASMI 2020
A2 - Lin, Kang-Ping
A2 - Liu, Ren-Shyan
A2 - Yang, Bang-Hung
PB - Springer Science and Business Media Deutschland GmbH
T2 - International conference of Federation of Asian Societies for Molecular Imaging, FASMI 2020
Y2 - 20 November 2020 through 22 November 2020
ER -