Clinicopathological features and prognosis in resectable synchronous and metachronous colorectal liver metastasis

Ming Shian Tsai, Yen Hao Su, Ming Chih Ho, Jin Tung Liang, Tzu Ping Chen, Hong Shiee Lai, Po Huang Lee

研究成果: 雜誌貢獻文章同行評審

159 引文 斯高帕斯(Scopus)


Introduction: Hepatic resection may offer long-term survival for patients with colorectal metastases. However, controversies exist regarding the prognostic factors. Herein, the impact of synchronicity of liver metastasis on patient clinicopathological features and prognosis was evaluated. Methods: One hundred and fifty-five patients who underwent hepatectomy for colon cancer metastasis, from 1995 to 2004, were enrolled in this study. Patients were divided into two groups: synchronous and metachronous colorectal liver metastasis. Patient demographics, the nature of the primary and metastatic tumors, surgery-related complications, and long-term outcome were analyzed. Results: Patients included in the synchronous group tended to be younger than those in the metachronous group. Compared to the metachronous group, patients in the synchronous group showed more metastases (P = 0.008) and bilobarly distributed metastases (P = 0.016). Bile leakage was the most common surgical complication. The estimated 5-year disease-free and overall survival rates were 16.8 and 41.1%, respectively. Univariate analysis indicated that synchronous metastases, advanced stage of the primary tumor, bilobar distribution of the metastases, more than three metastases, and colonic versus rectal location of the primary tumor were prognostic factors of shorter disease-free survival, but not overall survival. Multivariate analysis revealed that synchronous metastases and the advanced stage of the primary tumor were indicators for a worse disease-free survival. Conclusion: The synchronous presence of primary colon cancer and liver metastasis may indicate a more disseminated disease status and is associated with a shorter disease-free survival than metachronous metastasis. These patients may need more careful monitoring and aggressive chemotherapy following curative resection.
頁(從 - 到)786-794
期刊Annals of Surgical Oncology
出版狀態已發佈 - 2月 1 2007

ASJC Scopus subject areas

  • 手術
  • 腫瘤科


深入研究「Clinicopathological features and prognosis in resectable synchronous and metachronous colorectal liver metastasis」主題。共同形成了獨特的指紋。