Clinicopathologic factors related to metastasis in retinoblastoma

An Guor Wang, Wen Ming Hsu, Wei Wei Hsia, Jorn Hon Liu, May Yung Yen

研究成果: 雜誌貢獻文章同行評審

5 引文 斯高帕斯(Scopus)


Purpose: To investigate the orbital invasion and metastatic pattern in retinoblastoma, and to analyze the correlation with other pathologic and prognostic factors. Methods: Pathologic and admission records of 45 patients with a pathologically confirmed diagnosis of retinoblastoma during the past 20 years were reviewed. Clinical risk factors and pathologic findings were analyzed for association with tumor invasion/metastasis using chi-square, Fisher's exact, and Student's t tests. Results: Clinical risk factors such as exophthalmos, cataract, and pseudohypopyon were significantly correlated with tumor invasion/metastasis. The pathologic finding of choroid involvement was highly predictive of tumor invasion/metastasis. Delayed enucleation (>3 months) also was significantly correlated with tumor invasion/metastasis. Conclusion: Tumor invasion/metastasis is strongly associated with various ocular, pathologic, and treatment outcome factors. Identification of these risk factors may help plan treatment regimens.

頁(從 - 到)166-171
期刊Journal of Pediatric Ophthalmology and Strabismus
出版狀態已發佈 - 5月 2001

ASJC Scopus subject areas

  • 兒科、圍產兒和兒童健康
  • 眼科


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