TY - JOUR
T1 - Clinical correlates of arterial stiffness assessed by the cardio-ankle vascular index in peritoneal dialysis patients
AU - Tsai, Jen Pi
AU - Lai, Yu Hsien
AU - Wang, Chih Hsien
AU - Hsu, Bang Gee
AU - Fang, Te Chao
PY - 2011/9
Y1 - 2011/9
N2 - Objective: The cardio-ankle vascular index (CAVI) is a novel and accurate method, independent of the effect of blood pressure, and is used as a predictor of arterial stiffness (AS). However, the application of CAVI to identify the prevalence and clinical correlates of AS in peritoneal dialysis (PD) patients remains under investigation. The objective of this study was to explore the clinical correlates of PD patients with AS diagnosed by the CAVI examination compared with PD patients without AS. Materials and Methods: A total of 50 patients who had undergone PD for more than 3 months were enrolled in this cross-sectional study. AS was defined as a CAVI ≥ 9. The clinical correlations between CAVI and AS in PD patients were studied. Results: These PD patients had a high prevalence (42%) of AS. Age, systolic blood pressure, history of cardiovascular disease, hematocrit, glucose level, and phosphorus level were positively correlated with AS in PD patients compared with those without AS. Furthermore, multivariate regression analysis showed that age [adjusted odds ratio (OR). = 1.116, p= 0.010]; systolic blood pressure (adjusted OR. = 1.080, p= 0.010); hematocrit (adjusted OR. = 1.896, p= 0.006); and history of cardiovascular disease (adjusted OR. = 35.492, p= 0.013) were all independently correlated with AS in PD patients. Conclusion: The prevalence of AS in PD patients was high. Older age, elevated systolic blood pressure, hematocrit, and history of cardiovascular disease were positively related to the AS process shown by CAVI assessment in PD patients. However, further studies are needed to elucidate these factors, especially the hematocrit, affecting AS in PD patients after long-term follow-up.
AB - Objective: The cardio-ankle vascular index (CAVI) is a novel and accurate method, independent of the effect of blood pressure, and is used as a predictor of arterial stiffness (AS). However, the application of CAVI to identify the prevalence and clinical correlates of AS in peritoneal dialysis (PD) patients remains under investigation. The objective of this study was to explore the clinical correlates of PD patients with AS diagnosed by the CAVI examination compared with PD patients without AS. Materials and Methods: A total of 50 patients who had undergone PD for more than 3 months were enrolled in this cross-sectional study. AS was defined as a CAVI ≥ 9. The clinical correlations between CAVI and AS in PD patients were studied. Results: These PD patients had a high prevalence (42%) of AS. Age, systolic blood pressure, history of cardiovascular disease, hematocrit, glucose level, and phosphorus level were positively correlated with AS in PD patients compared with those without AS. Furthermore, multivariate regression analysis showed that age [adjusted odds ratio (OR). = 1.116, p= 0.010]; systolic blood pressure (adjusted OR. = 1.080, p= 0.010); hematocrit (adjusted OR. = 1.896, p= 0.006); and history of cardiovascular disease (adjusted OR. = 35.492, p= 0.013) were all independently correlated with AS in PD patients. Conclusion: The prevalence of AS in PD patients was high. Older age, elevated systolic blood pressure, hematocrit, and history of cardiovascular disease were positively related to the AS process shown by CAVI assessment in PD patients. However, further studies are needed to elucidate these factors, especially the hematocrit, affecting AS in PD patients after long-term follow-up.
KW - Arterial stiffness
KW - Cardio-ankle vascular index
KW - Dialysis
KW - Peritoneal dialysis
KW - Systolic blood pressure
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U2 - 10.1016/j.tcmj.2011.07.001
DO - 10.1016/j.tcmj.2011.07.001
M3 - Article
AN - SCOPUS:80053310855
SN - 1016-3190
VL - 23
SP - 73
EP - 76
JO - Tzu Chi Medical Journal
JF - Tzu Chi Medical Journal
IS - 3
ER -