Clinical characteristics and long-term outcome of cerebral cavernous malformations-related epilepsy

Yen Cheng Shih, Chien Chen Chou, Syu Jyun Peng, Hsiang Yu Yu, Sanford P.C. Hsu, Chun Fu Lin, Cheng Chia Lee, Huai Che Yang, Yi Chieh Chen, Shang Yeong Kwan, Chien Chen, Shuu Jiun Wang, Chung Jung Lin, Jiing Feng Lirng, Yang Hsin Shih, Der Jen Yen, Yo Tsen Liu

研究成果: 雜誌貢獻文章同行評審

4 引文 斯高帕斯(Scopus)


Objective: Cerebral cavernous malformations (CCMs) present variably, and epileptic seizures are the most common symptom. The factors contributing to cavernoma-related epilepsy (CRE) and drug resistance remain inconclusive. The outcomes of CRE after different treatment modalities have not yet been fully addressed. This study aimed to characterize the clinical features of patients with CRE and the long-term seizure outcomes of medical and surgical treatment strategies. Methods: This was a retrospective cohort of 135 patients with CCM who were diagnosed in 2007–2011 and followed up for 93.6 months on average. The patients were divided into drug-resistant epilepsy (DRE; n = 29), non-DRE (n = 45), and no epilepsy (NE; n = 61). Results: Temporal CCM was the factor most strongly associated with the development of both CRE and DRE. The majority of patients with single temporal CCMs had CRE (86.8%, n = 33), and 50% had DRE, whereas only 14.7% (n = 5) with a nontemporal supratentorial CCM had DRE (p
頁(從 - 到)2056-2067
出版狀態已發佈 - 8月 2022

ASJC Scopus subject areas

  • 神經內科
  • 神經病學(臨床)


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