摘要
CISD2, the causative gene for Wolfram syndrome 2 (WFS2), is a previously uncharacterized novel gene. Using a mouse genetic approach, this work demonstrated for the first time that Cisd2 is involved in mammalian life span control. Cisd2 deficiency in mice leads to mitochondrial breakdown and dysfunction; this is accompanied by cell death with autophagic features and these events precede the two earliest manifestations of nerve and muscle degeneration. Together, they lead to a panel of phenotypic features suggestive of premature aging. This work effectively links Cisd2 gene function, mitochondrial integrity and aging in mammals.
原文 | 英語 |
---|---|
頁(從 - 到) | 1043-1045 |
頁數 | 3 |
期刊 | Autophagy |
卷 | 5 |
發行號 | 7 |
DOIs | |
出版狀態 | 已發佈 - 10月 1 2009 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 細胞生物學
- 分子生物學