Circulating intercellular adhesion molecule-1 and E-selectin in patients with acute coronary syndrome

To characterize the role of circulating intercellular adhesion molecule-1 (ICAM-1) and E-selectin in patients with acute coronary syndrome, serum levels of ICAM-1 and E-selectin were measured by enzyme-linked immunosorbent assay (ELISA). Group 1 comprised 17 patients with acute myocardial infarction; group 2 included 17 patients with unstable angina; and group 3 included 19 control subjects. These 53 patients all had prolonged chest pain within 24 h and all underwent coronary angiography. Group 1 and 2 patients had significant coronary artery disease, while group 3 had normal coronary arteries. Blood samples were collected at the emergency department before antiplatelet agents were given. Serum levels of ICAM-1 were higher in group 1 and 2 (383±27 and 337±11 ng/mL, respectively) as compared with group 3 (282±18 ng/mL) (group 1 vs 3, p