TY - JOUR
T1 - Circuit Integration Initiation of New Hippocampal Neurons in the Adult Brain
AU - Yang, Chih Hao
AU - Di Antonio, Adrian
AU - Kirschen, Gregory W.
AU - Varma, Parul
AU - Hsieh, Jenny
AU - Ge, Shaoyu
N1 - Funding Information:
We thank Dr. Simon Halegoua for critical feedback on this manuscript and Dr. Maya Shelly for technical support of in vitro cell analysis. We also thank the members of Dr. S. Ge's and Dr. Q. Xiong's laboratories for valuable comments. This work was supported by the NIH (grants AG046875 and NS104868 to S.G. NS093992 to J.H. and NS089770 to S.G. and J.H.) and partially by the SUNY Brain Excellence. C.-H.Y. is under the support of MOST-103 (106)-2320-B-038-027-MY3. This work was also partially supported by funds from the Semmes Foundation, Inc. and the Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation (to J.H.). C.-H.Y. and S.G. conceived the project. C.-H.Y. A.D.A. and G.W.K. performed experiments and analyzed data. P.V. and J.H. provided RNA-seq data and analysis. C.-H.Y. A.D.A. and G.W.K. wrote the initial draft of the manuscript. All authors edited the manuscript and approved the final version. The authors declare no competing interests.
Funding Information:
We thank Dr. Simon Halegoua for critical feedback on this manuscript and Dr. Maya Shelly for technical support of in vitro cell analysis. We also thank the members of Dr. S. Ge’s and Dr. Q. Xiong’s laboratories for valuable comments. This work was supported by the NIH (grants AG046875 and NS104868 to S.G., NS093992 to J.H., and NS089770 to S.G. and J.H.) and partially by the SUNY Brain Excellence . C.-H.Y. is under the support of MOST-103 (106)-2320-B-038-027-MY3 . This work was also partially supported by funds from the Semmes Foundation, Inc. and the Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation (to J.H.).
Publisher Copyright:
© 2019 The Author(s)
PY - 2020/1/28
Y1 - 2020/1/28
N2 - Yang et al. show that prior to circuit integration, adult-born dentate granule cells undergo horizontal-to-radial transitioning, which is regulated by sphingolipid signaling via sphingosine-1-phosphate receptor 1.
AB - Yang et al. show that prior to circuit integration, adult-born dentate granule cells undergo horizontal-to-radial transitioning, which is regulated by sphingolipid signaling via sphingosine-1-phosphate receptor 1.
KW - adult hippocampal neurogenesis
KW - circuit integration initiation
KW - dentate granule cell
KW - electrophysiological maturation
KW - environmental enrichment
KW - G protein-coupled receptor
KW - hippocampus behavior-engaged activation
KW - lipidomics
KW - sphingosine-1-phosphate receptor 1
UR - http://www.scopus.com/inward/record.url?scp=85078353539&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85078353539&partnerID=8YFLogxK
U2 - 10.1016/j.celrep.2019.12.084
DO - 10.1016/j.celrep.2019.12.084
M3 - Article
C2 - 31995766
AN - SCOPUS:85078353539
SN - 2211-1247
VL - 30
SP - 959-968.e3
JO - Cell Reports
JF - Cell Reports
IS - 4
ER -