摘要
In the present study, we demonstrate that the Ca2+-inhibitable adenylyl cyclase (AC) activity in the striatum exhibits a daily oscillation with a peak occurring around 10:00 h. A circadian fluctuation of the AC activity evoked by an A2a adenosine-selective agonist was also observed. Intrastriatal injection of an A2a-selective adenosine agonist or antagonist during the interval in which the Ca2+-inhibitable AC activity was at its peak resulted in a more significant alteration of locomotor activity than those observed at a later interval. The marked circadian variation in the Ca2+-inhibitable AC activity in the striatum appears to cause a circadian fluctuation in the action of at least one neuromodulator.
原文 | 英語 |
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頁(從 - 到) | 205-208 |
頁數 | 4 |
期刊 | FEBS Letters |
卷 | 385 |
發行號 | 3 |
DOIs | |
出版狀態 | 已發佈 - 5月 6 1996 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 生物物理學
- 結構生物學
- 生物化學
- 分子生物學
- 遺傳學
- 細胞生物學