Cigarette smoking stimulates lipoxygenase but not cyclooxygenase pathway in platelets

Wen Chang Chang; Shoshi Fukuda; Hsin Hsiung Tai

doi:10.1016/S0006-291X(83)80172-7

Cigarette smoking stimulates lipoxygenase but not cyclooxygenase pathway in platelets

Wen Chang Chang, Shoshi Fukuda, Hsin Hsiung Tai

研究成果: 雜誌貢獻 › 文章 › 同行評審

2 引文斯高帕斯（Scopus）

摘要

Male rats were exposed to freshly generated cigarette smoke once daily for 4 to 8 weeks. Inhalation of smoke was verified by elevated level of carboxyhemoglobin. Arachidonate metabolism through lipoxygenase and cyclooxygenase pathways in platelets was determined. Cigarette smoking increased 12-lipoxygenase activity significantly without affecting the cyclooxygenase pathway. In view of platelet-leukocyte interactions and potent chemotactic activity of 12-HETE for aortic smooth muscle cell migration, increased 12-lipoxygenase activity may predispose individuals to atherosclerosis, thromboembolism and emphysema commonly found in smokers.

原文	英語
頁（從 - 到）	499-505
頁數	7
期刊	Biochemical and Biophysical Research Communications
卷	115
發行號	2
DOIs	https://doi.org/10.1016/S0006-291X(83)80172-7
出版狀態	已發佈 - 9月 15 1983
對外發佈	是

ASJC Scopus subject areas

生物物理學
生物化學
分子生物學
細胞生物學

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10.1016/S0006-291X(83)80172-7

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引用此

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title = "Cigarette smoking stimulates lipoxygenase but not cyclooxygenase pathway in platelets",

abstract = "Male rats were exposed to freshly generated cigarette smoke once daily for 4 to 8 weeks. Inhalation of smoke was verified by elevated level of carboxyhemoglobin. Arachidonate metabolism through lipoxygenase and cyclooxygenase pathways in platelets was determined. Cigarette smoking increased 12-lipoxygenase activity significantly without affecting the cyclooxygenase pathway. In view of platelet-leukocyte interactions and potent chemotactic activity of 12-HETE for aortic smooth muscle cell migration, increased 12-lipoxygenase activity may predispose individuals to atherosclerosis, thromboembolism and emphysema commonly found in smokers.",

author = "Chang, {Wen Chang} and Shoshi Fukuda and Tai, {Hsin Hsiung}",

note = "Funding Information: We are greatly indebted to Ms. Sharon Parker for her excellent technical assistance and to Ms. Laurie Benton for her preparation of the manuscript. We are also grateful to Mr. Phil Wiseman for smoke inhalation. This study was supported in part by KTRB grant 4B506 from the Kentucky Tobacco Research Board.",

year = "1983",

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day = "15",

doi = "10.1016/S0006-291X(83)80172-7",

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AU - Chang, Wen Chang

AU - Fukuda, Shoshi

AU - Tai, Hsin Hsiung

N1 - Funding Information: We are greatly indebted to Ms. Sharon Parker for her excellent technical assistance and to Ms. Laurie Benton for her preparation of the manuscript. We are also grateful to Mr. Phil Wiseman for smoke inhalation. This study was supported in part by KTRB grant 4B506 from the Kentucky Tobacco Research Board.

PY - 1983/9/15

Y1 - 1983/9/15

N2 - Male rats were exposed to freshly generated cigarette smoke once daily for 4 to 8 weeks. Inhalation of smoke was verified by elevated level of carboxyhemoglobin. Arachidonate metabolism through lipoxygenase and cyclooxygenase pathways in platelets was determined. Cigarette smoking increased 12-lipoxygenase activity significantly without affecting the cyclooxygenase pathway. In view of platelet-leukocyte interactions and potent chemotactic activity of 12-HETE for aortic smooth muscle cell migration, increased 12-lipoxygenase activity may predispose individuals to atherosclerosis, thromboembolism and emphysema commonly found in smokers.

AB - Male rats were exposed to freshly generated cigarette smoke once daily for 4 to 8 weeks. Inhalation of smoke was verified by elevated level of carboxyhemoglobin. Arachidonate metabolism through lipoxygenase and cyclooxygenase pathways in platelets was determined. Cigarette smoking increased 12-lipoxygenase activity significantly without affecting the cyclooxygenase pathway. In view of platelet-leukocyte interactions and potent chemotactic activity of 12-HETE for aortic smooth muscle cell migration, increased 12-lipoxygenase activity may predispose individuals to atherosclerosis, thromboembolism and emphysema commonly found in smokers.

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Cigarette smoking stimulates lipoxygenase but not cyclooxygenase pathway in platelets

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