@article{ff1d362d38d74cf39045871e7c2d5a55,
title = "Chronic hepatitis B virus infection associated with increased colorectal cancer risk in Taiwanese population",
abstract = "Chronic hepatitis B virus (HBV) infections and colorectal cancer (CRC) are prevalent in Taiwan. We carried out a population-based case-control study to assess the association between HBV infection and CRC risk. Using the National Health Insurance Research Database of Taiwan, we identified 69,478 newly diagnosed patients with CRC from 2005 to 2011. We further randomly selected 69,478 age- and gender-matched controls without CRC from the same database. Odds ratios (ORs) were calculated to evaluate the association between chronic HBV infection and CRC using a logistic regression analysis. HBV infection was found to be associated with the risk of CRC (OR = 1.27, 95% confidence interval (CI) = 1.20–1.33). This relationship was similar in men and women. Age-specific analysis revealed that the CRC risk associated with HBV decreased with age. The adjusted ORs for patients aged <55, 55–64, and 65–74 years were 1.63 (95% CI = 1.48–1.79), 1.24 (95% CI = 1.13–1.37), and 1.02 (95% = 0.92–1.13), respectively. In conclusion, this study suggests that chronic HBV infection is significantly associated with an increased risk of CRC. Monitoring the risk of CRC development in young patients with HBV infection is crucial.",
keywords = "Case-control study, Colorectal cancer, Hepatitis B virus, Population-based",
author = "Su, {Fu Hsiung} and Le, {Thi Nga} and Muo, {Chih Hsin} and Te, {Sister Arlene} and Sung, {Fung Chang} and Yeh, {Chih Ching}",
note = "Funding Information: Funding: This study was funded by the Ministry of Science and Technology (MOST105-2314-B-038-038), the Health and Welfare Surcharge of Tobacco Products (MOHW107-TDU-B-212-114020 and MOHW108-TDU-B-212-124020), the Ministry of Health and Welfare, Taiwan (MOHW108-TDU-B-212-133004), China Medical University Hospital (DMR-108-024 and DMR-108-111), Academia Sinica Taiwan Biobank Stroke Biosignature Project (BM10701010021), the Taiwan Clinical Trial Consortium for Stroke (MOST 107-2321-B-039-004), Tseng-Lien Lin Foundation, Taichung, Taiwan, Taiwan Brain Disease Foundation, Taipei, Taiwan, and Katsuzo and Kiyo Aoshima Memorial Funds, Japan. Funding Information: Acknowledgments: We thank the Taiwan National Health Insurance Research Database for providing the dataset used in this study. This study was approved by the Institutional Review Board of China Medical University and Hospital Research Ethics Committee (IRB approval number: CMU-REC-101-012). This manuscript was edited by Wallace Academic Editing, Jonathan C. Su, and AJ Goodwin. Publisher Copyright: {\textcopyright} 2020 by the authors.",
year = "2020",
month = jan,
day = "1",
doi = "10.3390/v12010097",
language = "English",
volume = "12",
journal = "Viruses",
issn = "1999-4915",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "1",
}
