摘要
This study investigated the effect of physical training on endothelial function in spontaneously hypertensive rats (SHR). After 3 months, in conscious trained- and untrained-SHR body weight, systolic blood pressure and heart rate were 220 ± 6 g vs. 271 ± 9 g, 172 ± 7 mmHg vs. 210 ± 8 mmHg and 314 ± 10 vs. 348 ± 12 beats/min, respectively. In vitro, the dose-response curves of norepinephrine in isolated intact aortic and mesenteric rings from the exercise trained-SHR were significantly lower than those from the untrained-SHR. With denuded preparations, norepinephrine concentration-response curves were shifted to the left both in the trained- and untrained-SHR. This shift in the trained-SHR exceeded that in the untrained-SHR. The vasodilator response to acetylcholine in the trained-SHR was significantly greater than that in the untrained-SHR. Either Nω-nitro-L-arginine (100 μmol/l) or methylene blue (10 μmol/l) inhibited acetylcholine-induced vasodilator effect in aorta of trained- and untrained-SHR, but not in mesenteric artery of trained-SHR. Tetraethylammonium (10 mmol/l) inhibited significantly the Nω-nitro-L-arginine and methylene blue-resistant relaxation in mesenteric artery of trained-SHR,but not by indomethacin (10 μmol/l). Collectively, these data demonstrate that chronic exercise increases EDRF/EDHF production (presumably by increasing endothelial shear stress), and may contribute to the enhanced effects of post-exercise hypotension.1.
原文 | 英語 |
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頁(從 - 到) | 2205-2213 |
頁數 | 9 |
期刊 | Life Sciences |
卷 | 57 |
發行號 | 24 |
DOIs | |
出版狀態 | 已發佈 - 11月 3 1995 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 生物化學、遺傳與分子生物學 (全部)
- 藥理學、毒理學和藥劑學 (全部)
- 藥理