Chitosan and dextran hydrogel as a filler for possible application in orthopedic implantation surgery

Abigail F. Wu, Audrey L. Wu, Tsu Te Yeh, Pei Chun Wong, Jia Lin Wu

研究成果: 雜誌貢獻文章同行評審

摘要

To enhance osteointegration between bone implants and bone tissues in implantation surgery, this study aimed to develop a hydrogel using chitosan and dextran to improve the cell proliferative ability, cell migratory capacity, and cell osteogenic ability. Herein, we developed two different hydrogel compositions with three different amounts of magnesium sulfate to produce six hydrogels for application as a filler for total knee replacement surgery to replace bone cement. The swelling property, degradation behavior, composition, and structure of the hydrogel were systemically investigated. Moreover, an MTT assay, scratch test, and alizarin red S staining were conducted to analyze the cell viability, migratory ability, and osteogenic response after being stimulated by the hydrogel. MC3T3-E1 preosteoblasts exhibited significantly improved cell proliferation, migratory capacity, osteogenesis, and mineralization due to MgSO4 in the hydrogel. Our work provides insights into the development of biomimetic and osteogenic hydrogels for bone integration in implantation surgery.
原文英語
頁(從 - 到)358-367
頁數10
期刊Journal of Bioactive and Compatible Polymers
38
發行號5
DOIs
出版狀態已發佈 - 9月 2023

ASJC Scopus subject areas

  • 生物工程
  • 生物材料
  • 聚合物和塑料
  • 材料化學

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