Measurement of tissue radiation damage quantitatively in radiation therapy is very important to optimize the therapeutic treatment. Ionized radiation induces homogenization of the extracellular matrix which is synthesized by fibroblast and the randomization of the orientation of the collagen fibers in dermis. If the dermis is exposed by ionized radiation, a thermal acoustic shear wave which propagates in dermis becomes harmonic wave; Otherwise, an inharmonic wave is expected because of inhomogeneous and the anisotropic properties of dermis. A polarized optical heterodyne interferometer was setup in order to measure the transverse displacement of the shear wave in order to analyze the propagation mode of the shear wave in dermis. The detection sensitivity of the displacement was 1 nm and the dynamic range was 300 nm in this arrangement. The lowest dose that can be detected by the exposure of 4 MeV radiation on porcine dermis was 1 cGy.
|頁（從 - 到）||248-254|
|期刊||Proceedings of SPIE - The International Society for Optical Engineering|
|出版狀態||已發佈 - 1月 1 2000|
|事件||Optical Sensing, Imaging, and Manipulation for Biological and Biomedical Applications - Taipei, Taiwan|
持續時間: 7月 26 2000 → 7月 28 2000
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