TY - CHAP
T1 - Chapter 8
T2 - Role of kynurenine pathway in allergy
AU - Kawasaki, Hirokazu
AU - Huang, Shau Ku
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Tryptophan catabolism, including kynurenine pathway, is known to be involved in immunoregulation and its metabolites play a role in immune modulation. In the context of allergic diseases, it has been proposed that tryptophan degradation pathway, rather than tryptophan deprivation itself, plays an important role in tolerance induction during allergen-specifi c immunotherapy, which is, by far, the only causal treatment of allergic diseases. In addition, it has recently been demonstrated that kynurenine and, perhaps, its metabolites can act through the aryl hydrocarbon receptor, a unique cellular chemical sensor, and regulate immune functions. The present review intends to highlight the recent development on the involvement of kynurenine pathway in the regulation of allergic diseases.
AB - Tryptophan catabolism, including kynurenine pathway, is known to be involved in immunoregulation and its metabolites play a role in immune modulation. In the context of allergic diseases, it has been proposed that tryptophan degradation pathway, rather than tryptophan deprivation itself, plays an important role in tolerance induction during allergen-specifi c immunotherapy, which is, by far, the only causal treatment of allergic diseases. In addition, it has recently been demonstrated that kynurenine and, perhaps, its metabolites can act through the aryl hydrocarbon receptor, a unique cellular chemical sensor, and regulate immune functions. The present review intends to highlight the recent development on the involvement of kynurenine pathway in the regulation of allergic diseases.
KW - Allergen-specifi c immunotherapy
KW - Allergic diseases
KW - Allergy
KW - Aryl hydrocarbon receptor
KW - Immune tolerance
KW - Kynurenine
KW - Mast cells
UR - http://www.scopus.com/inward/record.url?scp=84957033055&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84957033055&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-11870-3_8
DO - 10.1007/978-3-319-11870-3_8
M3 - Chapter
AN - SCOPUS:84957033055
SN - 9783319118697
SP - 109
EP - 119
BT - Targeting the Broadly Pathogenic Kynurenine Pathway
PB - Springer International Publishing
ER -