Chaperone-mediated autophagy degrade Dicer to promote breast cancer metastasis

Chih Ming Su, Tung Wei Hsu, Hsin An Chen, Wan Yu Wang, Chih Yang Huang, Chih Chiang Hung, Ming Hsin Yeh, Yen Hao Su, Ming Te Huang, Po Hsiang Liao

研究成果: 雜誌貢獻文章同行評審

5 引文 斯高帕斯(Scopus)

摘要

Metastasis in breast cancer usually lead to the majority of deaths on clinical patients. Accordingly, diagnosis of metastasis at the early stage in breast cancer is important to improve the prognosis. We observed that Dicer protein levels are significant decrease in highly invasive breast cancer cells and usually correlated with poor clinical outcomes. Following, we aim to clarify the molecular regulatory mechanism of this phenomenon in breast cancer to provide a new therapeutic target. In this study, we obtained that Dicer expression correlated with metastasis and invasion without affect cell stability in breast cancer cells. Importantly, we identified the regulatory mechanism of Dicer protein degradation, the chaperone-mediated autophagy (CMA)-mediated degradation that is major mechanism to decrease Dicer protein expression and lead to cancer metastasis. We discovered that heat shock cognate 71-kDa protein (Hsc70) which as a CMA-related factor interacts with the CMA-targeting motif I333A/K334A on Dicer to promote degradation through CMA. Taken together, our findings hint that Dicer highly correlated with cancer metastasis, we reveal the tumor-promoting effect of CMA-mediated Dicer degradation in breast cancer.
原文英語
頁(從 - 到)829-841
頁數13
期刊Journal of Cellular Physiology
238
發行號4
DOIs
出版狀態接受/付印 - 2023

ASJC Scopus subject areas

  • 生理學
  • 臨床生物化學
  • 細胞生物學

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