Changes in prostaglandin E1 stimulation of glucose oxidation in rat adipocytes during maturation and aging

Wen Chang Chang, George S. Roth

研究成果: 雜誌貢獻文章同行評審

17 引文 斯高帕斯(Scopus)

摘要

Prostaglandin E1 stimulates glucose oxidation in isolated rat adipocytes in a time and concentration dependent manner. Maximal stimulation requires 2 hours exposure to prostaglandin, although effects can be detected by 0.5 hours or earlier. In contrast to prostaglandin E1, prostaglandin F2α has essentially no effect on glucose oxidation. Maximal stimulation by prostaglandin E1 at all ages tested occurs at concentrations of 10-5 - 10-4M. Stimulation is greatest in cells of mature (10-12 month old) animals at 81 ± 9% above basal levels of glucose oxidation. This is to reduced to 48 ± 8% in cells of senescent (23-26 month old) animals, and at 23 ± 18% in cells of young (2-3 month old) rats is not significantly different from basal oxidation in most animals. These results are consistent with data for adipocytes and other cell types indicating that responsiveness to certain hormones is altered during maturation and aging.

原文英語
頁(從 - 到)623-627
頁數5
期刊Life Sciences
28
發行號6
DOIs
出版狀態已發佈 - 2月 9 1981
對外發佈

ASJC Scopus subject areas

  • 一般藥理學、毒理學和製藥學
  • 一般生物化學,遺傳學和分子生物學

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