Cerebral toxocariasis: Silent progression to neurodegenerative disorders?

Chia Kwung Fan, Celia V. Holland, Karen Loxton, Ursula Barghouth

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119 引文 斯高帕斯(Scopus)


Toxocara canis and T. cati are highly prevalent nematode infections of the intestines of dogs and cats. In paratenic hosts, larvae do not mature in the intestine but instead migrate through the somatic tissues and organs of the body. The presence of these migrating larvae can contribute to pathology. Toxocara larvae can invade the brains of humans, and while case descriptions of cerebral toxocariasis are historically rare, improved diagnosis and greater awareness have contributed to increased detection. Despite this, cerebral or neurological toxocariasis (NT) remains a poorly understood phenomenon. Furthermore, our understanding of cognitive deficits due to toxocariasis in human populations remains particularly deficient. Recent data describe an enhanced expression of biomarkers associated with brain injury, such as GFAP, AβPP, transforming growth factor β1 (TGF-β1), NF-L, S100B, tTG, and p-tau, in mice receiving even low doses of Toxocara ova. Finally, this review outlines a hypothesis to explore the relationship between the presence of T. canis larvae in the brain and the progression of Alzheimer's disease (AD) due to enhanced AD-associated neurodegenerative biomarker expression.
頁(從 - 到)663-686
期刊Clinical Microbiology Reviews
出版狀態已發佈 - 2015

ASJC Scopus subject areas

  • 流行病學
  • 免疫學與微生物學 (全部)
  • 公共衛生、環境和職業健康
  • 微生物學(醫學)
  • 傳染性疾病


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