@article{e85e80c2c73e4cc9a1ec4b73a1fda0f1,
title = "Cerebral Motor Functional Connectivity at the Acute Stage: An Outcome Predictor of Ischemic Stroke",
abstract = "Sixty-seven patients with first acute ischemic stroke onset between 3 to 7 days and 25 age- and sex- matched controls were analyzed for the performance of a resting-state functional MRI to investigate whether the functional connectivity (FC) of the motor network in acute ischemic stroke is independently associated with functional outcomes. The FC of cortical motor network and default mode network was analyzed. The FC was compared between controls, patients with favorable outcomes (modified Rankin Scale, mRS ≤1), and patients with unfavorable outcomes (mRS ≥2) at 3 months. Of the 67 patients, 23 (34%) exhibited unfavorable outcomes. In multivariate analysis, the FC between ipsilesional primary motor cortex (M1) and contralesional dorsal premotor area (PMd) ≤0.63, were independently associated with unfavorable outcomes (odds ratio = 6.32, P = 0.032), whereas the FC of default mode network was not different between groups. The interhemispheric FC of the motor network is an independent predictor of functional outcomes in patients with acute ischemic stroke.",
author = "Chi, {Nai Fang} and Ku, {Hsiao Lun} and Chen, {David Yen Ting} and Tseng, {Ying Chi} and Chen, {Chi Jen} and Lin, {Ying Chin} and Hsieh, {Yi Chen} and Lung Chan and Chiou, {Hung Yi} and Hsu, {Chung Y.} and Hu, {Chaur Jong}",
note = "Funding Information: We thank Prof. Chia-Shu Lin (National Yang-Ming University) and Ms. Yi-Tien Lee (Shuang Ho Hospital) for the assistance of figures production, Prof. Chang-Wei Wu (Taipei Medical University) and Dr. Nai-Wen Chi (National Taiwan University) for the assistance in fMRI analytic works. This study was supported by the Taiwan Ministry of Science and Technology (MOST 103-2314-B-038-004, MOST 105-2314-B-038-003, MOST 105-2314-B-038-007), Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence (MOHW105-TDU-B-212-113004); China Medical University Hospital, Academia Sinica Taiwan Biobank, Stroke Biosignature Project (BM10601010036); and Taiwan Clinical Trial Consortium for Stroke (MOST 106-2321-B-039-005). Publisher Copyright: {\textcopyright} 2018, The Author(s).",
year = "2018",
month = dec,
day = "1",
doi = "10.1038/s41598-018-35192-y",
language = "English",
volume = "8",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}