TY - JOUR
T1 - Cerebral Microbleeds are Associated with Postural Instability and Gait Disturbance Subtype in People with Parkinson's Disease
AU - Chiu, Wei Ting
AU - Chan, Lung
AU - Wu, Dean
AU - Ko, Tzu Hsiang
AU - Chen, David Yen Ting
AU - Hong, Chien Tai
N1 - © 2019 S. Karger AG, Basel.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Objectives: The motor symptoms of Parkinson's disease (PD) vary among patients and have been categorized into 3 subtypes: tremor dominant, akinetic rigidity, and postural instability and gait disturbance (PIGD). Cerebral microbleed (CMB) is prevalent in people with PD and is associated with some nonmotor symptoms. The present study investigated the association between CMB and the motor subtypes of PD. Materials and Methods: From 2009 to 2017, medical records and brain magnetic resonance imaging (MRI) reports of 134 Taiwanese people with early-and mid-stage PD were reviewed. CMBs were quantified according to the Microbleed Anatomical Rating Scale through susceptibility-weighted MRI. Motor subtypes were determined by medical chart review. Student's t test and multivariable logistic regression were used to analyze the association between the motor subtypes and CMB. Statistical analyses were performed using SPSS 19.0. Results: Overall, 72 (53.7%) participants were women with a mean age of 69.5 ± 9.8 years. The prevalence of CMB was 33.6%, and lobar, deep, and infratentorial CMBs comprised 21.6, 19.4, and 11.9% of cases, respectively. PIGD subtype PD was associated with a significantly higher prevalence of any CMB as well as deep or lobar CMB. After adjustment for age and sex, the PIGD subtype was significantly positively associated with the presence of any, deep, and white matter (WM) and thalamic CMB. Conclusions: CMB was prevalent in Taiwanese people with early-and mid-stage PD, especially the PIGD subtype. Deep, especially thalamic and WM, CMBs exhibited the highest association with the PIGD subtype.
AB - Objectives: The motor symptoms of Parkinson's disease (PD) vary among patients and have been categorized into 3 subtypes: tremor dominant, akinetic rigidity, and postural instability and gait disturbance (PIGD). Cerebral microbleed (CMB) is prevalent in people with PD and is associated with some nonmotor symptoms. The present study investigated the association between CMB and the motor subtypes of PD. Materials and Methods: From 2009 to 2017, medical records and brain magnetic resonance imaging (MRI) reports of 134 Taiwanese people with early-and mid-stage PD were reviewed. CMBs were quantified according to the Microbleed Anatomical Rating Scale through susceptibility-weighted MRI. Motor subtypes were determined by medical chart review. Student's t test and multivariable logistic regression were used to analyze the association between the motor subtypes and CMB. Statistical analyses were performed using SPSS 19.0. Results: Overall, 72 (53.7%) participants were women with a mean age of 69.5 ± 9.8 years. The prevalence of CMB was 33.6%, and lobar, deep, and infratentorial CMBs comprised 21.6, 19.4, and 11.9% of cases, respectively. PIGD subtype PD was associated with a significantly higher prevalence of any CMB as well as deep or lobar CMB. After adjustment for age and sex, the PIGD subtype was significantly positively associated with the presence of any, deep, and white matter (WM) and thalamic CMB. Conclusions: CMB was prevalent in Taiwanese people with early-and mid-stage PD, especially the PIGD subtype. Deep, especially thalamic and WM, CMBs exhibited the highest association with the PIGD subtype.
KW - Cerebral microbleeds
KW - Parkinson's disease
KW - Susceptibilityweighted magnetic resonance imaging
KW - Prevalence
KW - Gait Disorders, Neurologic/etiology
KW - Humans
KW - Middle Aged
KW - Logistic Models
KW - Male
KW - Cerebral Hemorrhage/complications
KW - Postural Balance/physiology
KW - Parkinson Disease/complications
KW - Female
KW - Aged
UR - http://www.scopus.com/inward/record.url?scp=85064042095&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064042095&partnerID=8YFLogxK
U2 - 10.1159/000499378
DO - 10.1159/000499378
M3 - Article
C2 - 30928974
AN - SCOPUS:85064042095
SN - 0014-3022
VL - 80
SP - 335
EP - 340
JO - European Neurology
JF - European Neurology
IS - 5-6
ER -