Cell migration on nanophase-separated poly(carbonate urethane)s

Shan Hui Hsu, Chien An Chen, Chi Nan Chao, Chung Huang Chen, Jeng Jiann Chiu

研究成果: 雜誌貢獻文章同行評審

9 引文 斯高帕斯(Scopus)


Nanophase separation has been suggested to influence the biological performance of polyurethanes. Several 4,4′-diphenylmethane diisocyanate-based poly(carbonate urethane)s (PCU) that exhibited various degrees of nanophase separation have been synthesized in our previous work, and the promoting effect of nanophase separation on cell adhesion and proliferation has been demonstrated. Among these PCU, two with the most distinct nanophase separation were selected in this work for cell migration studies using a wound-healing model. Human umbilical vein endothelial cells were found to migrate much faster and exhibit more intense actin stress fibers in their central region when cultured on the PCU with a greater degree of nanophase separation. These cellular events appeared to be associated with a higher level of endothelial constitutive nitric oxide synthase (eNOS) expression in the cells cultured on the more nanophase-separated material.

頁(從 - 到)15-21
期刊Journal of Medical and Biological Engineering
出版狀態已發佈 - 3月 1 2007

ASJC Scopus subject areas

  • 生物醫學工程


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