摘要
Nonsteroidal anti-inflammatory drugs (NSAIDs), including ketoprofen, are widely used in clinical medicine. However, these drugs may damage the gastrointestinal mucosa. Some reports have suggested that intestinal diseases, such as ulcers, are associated with lipid peroxidation and oxidative damage in the mucosa. Phytochemicals, such as polyphenols, are common dietary antioxidants that possess many beneficial characteristics, such as antioxidant and anti-inflammatory capabilities. The objective of this study was to investigate the protective effects of polyphenols on ketoprofen-induced oxidative damage in the gastrointestinal mucosa. We evaluated the effects of catechin, theaflavin, malvidin, cyanidin and apigenin on the activity of antioxidant enzymes in human intestinal-407 (Int-407) cells and rat primary gastric cells treated with ketoprofen. The results indicated that catechin significantly (P
原文 | 英語 |
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頁(從 - 到) | 475-483 |
頁數 | 9 |
期刊 | Journal of Nutritional Biochemistry |
卷 | 24 |
發行號 | 2 |
DOIs | |
出版狀態 | 已發佈 - 2月 2013 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 生物化學
- 臨床生物化學
- 分子生物學
- 內分泌學、糖尿病和代謝
- 營養與營養學