TY - JOUR
T1 - Cardiovascular risk and comorbidities in patients with rosacea
T2 - A systematic review and meta-analysis
AU - Tsai, Tsung Yu
AU - Chiang, Ying Yi
AU - Huang, Yu Chen
N1 - Funding Information:
The authors thank Taipei Medical University and Wan Fang Hospital, Taipei Medical University for financial support under grant number 108TMU-WFH-02, which made this study possible.
Publisher Copyright:
© 2020, Medical Journals/Acta D-V. All rights reserved.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020
Y1 - 2020
N2 - The association between rosacea and cardiovascular disease remains controversial. A systematic review and meta-analysis of the literature, from inception to 15 February 2020, was performed to compare cardiovascular risk and comorbidities in individuals with and without rosacea. Twelve studies, involving 40,752 patients with rosacea, were included. Compared with con-trols, patients with rosacea had higher systolic blood pressure (standardized mean difference (SMD) 0.293, 95% confidence interval (CI) 0.054–0.532), diastolic blood pressure (SMD 0.309, 95% CI 0.003–0.615), to-tal cholesterol (SMD 1.147, 95% CI 0.309–1.984), low-density lipoprotein (SMD 0.792, 95% CI 0.174–1.409), C-reactive protein (SMD 0.26, 95% CI 0.099–0.421), greater epicardial fat thickness (SMD 1.945, 95% CI 1.595–2.296), and higher incidence of hypertension (odds ratio (OR) 1.204, 95% CI 1.097–1.332) and insulin resistance (OR 2.338, 95% CI 1.187–4.605). This study reveals that patients with rosacea are predis-posed to increased subclinical cardiovascular risk.
AB - The association between rosacea and cardiovascular disease remains controversial. A systematic review and meta-analysis of the literature, from inception to 15 February 2020, was performed to compare cardiovascular risk and comorbidities in individuals with and without rosacea. Twelve studies, involving 40,752 patients with rosacea, were included. Compared with con-trols, patients with rosacea had higher systolic blood pressure (standardized mean difference (SMD) 0.293, 95% confidence interval (CI) 0.054–0.532), diastolic blood pressure (SMD 0.309, 95% CI 0.003–0.615), to-tal cholesterol (SMD 1.147, 95% CI 0.309–1.984), low-density lipoprotein (SMD 0.792, 95% CI 0.174–1.409), C-reactive protein (SMD 0.26, 95% CI 0.099–0.421), greater epicardial fat thickness (SMD 1.945, 95% CI 1.595–2.296), and higher incidence of hypertension (odds ratio (OR) 1.204, 95% CI 1.097–1.332) and insulin resistance (OR 2.338, 95% CI 1.187–4.605). This study reveals that patients with rosacea are predis-posed to increased subclinical cardiovascular risk.
KW - Cardiovascular disease
KW - Dyslipidaemia
KW - Hyperten-sion
KW - Meta-analysis
KW - Risk factor
KW - Rosacea
KW - Systematic review
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U2 - 10.2340/00015555-3668
DO - 10.2340/00015555-3668
M3 - Article
C2 - 33073295
AN - SCOPUS:85094221169
SN - 0001-5555
VL - 100
SP - 1
EP - 7
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
IS - 17
M1 - adv00300
ER -
