TY - JOUR
T1 - Cardiovascular autonomic neuropathy, autonomic symptoms and diabetic complications in 674 type 2 diabetes
AU - Chen, Hung Ta
AU - Lin, Hong Da
AU - Won, Justin G.S.
AU - Lee, Chen Hsen
AU - Wu, Shiao Chi
AU - Lin, Jiun Dian
AU - Juan, Li Ying
AU - Ho, Low Tone
AU - Tang, Kam Tsun
N1 - Funding Information:
This work was supported by Taipei Veterans General Hospital Grant VGH-95-D003. The authors thank Miss Pui-Ching Lee, Biostatistics Task Force, Taipei Veteran General Hospital, for assistance with biostatistics analysis; and Miss Sheng-Hung Lee, Division of Endocrine and Metabolism, Taipei Veteran General Hospital, for studying autonomic function of these patients.
PY - 2008/11
Y1 - 2008/11
N2 - Aims: To determine the relationships between cardiovascular autonomic neuropathy (CAN) and autonomic symptoms, clinical parameters and diabetic complications in type 2 diabetes (T2DM). Methods: The results of autonomic symptoms, clinical parameters, diabetes complications and cardiovascular reflex (CVR) tests of 674 T2DM were analyzed. Results: Significant correlations were found between CAN risk and age (p = 0.019), duration of diabetes (p = 0.008), HbA1c (p < 0.001), systolic blood pressure (p = 0.006), nephropathy (p < 0.001), retinopathy (p < 0.001), and QTc interval (p < 0.001), but not BMI and hyperlipidemia. Patients with retinopathy or proteinuria had increase risk of CAN, and proliferative diabetic retinopathy (PDR) was the most significant risk factor (odds ratio: 6.85; 95% CI: 2.32-20.20) for CAN. Eighty-three percent of patients complained of autonomic symptoms; and the more symptoms complained, the higher the prevalence of CAN. Impotence was the only single symptom associated with CAN risk. Additional CAN risks were also observed when patients with multiple symptoms and/or complications in combinations. Conclusions: Our results implied that patients with multiple symptoms and/or complications in combinations have increased CAN risk, and this may provide additional information for clinicians to identify T2DM at risk of having CAN.
AB - Aims: To determine the relationships between cardiovascular autonomic neuropathy (CAN) and autonomic symptoms, clinical parameters and diabetic complications in type 2 diabetes (T2DM). Methods: The results of autonomic symptoms, clinical parameters, diabetes complications and cardiovascular reflex (CVR) tests of 674 T2DM were analyzed. Results: Significant correlations were found between CAN risk and age (p = 0.019), duration of diabetes (p = 0.008), HbA1c (p < 0.001), systolic blood pressure (p = 0.006), nephropathy (p < 0.001), retinopathy (p < 0.001), and QTc interval (p < 0.001), but not BMI and hyperlipidemia. Patients with retinopathy or proteinuria had increase risk of CAN, and proliferative diabetic retinopathy (PDR) was the most significant risk factor (odds ratio: 6.85; 95% CI: 2.32-20.20) for CAN. Eighty-three percent of patients complained of autonomic symptoms; and the more symptoms complained, the higher the prevalence of CAN. Impotence was the only single symptom associated with CAN risk. Additional CAN risks were also observed when patients with multiple symptoms and/or complications in combinations. Conclusions: Our results implied that patients with multiple symptoms and/or complications in combinations have increased CAN risk, and this may provide additional information for clinicians to identify T2DM at risk of having CAN.
KW - Autonomic symptoms
KW - Cardiovascular autonomic neuropathy
KW - Cardiovascular reflex test
KW - Diabetic nephropathy
KW - Diabetic retinopathy
UR - http://www.scopus.com/inward/record.url?scp=54549113047&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=54549113047&partnerID=8YFLogxK
U2 - 10.1016/j.diabres.2008.08.012
DO - 10.1016/j.diabres.2008.08.012
M3 - Article
C2 - 18824270
AN - SCOPUS:54549113047
SN - 0168-8227
VL - 82
SP - 282
EP - 290
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
IS - 2
ER -
