Capnesterones A and B, new steroids isolated from the soft coral Capnella imbricata

Ting Yu Cheng; Chia Jung Yang; Po Jen Chen; Yu Li Chen; Bo Rong Peng; Te An Kung; Zhi Hong Wen; Kuei Hung Lai; Hsu Ming Chung

doi:10.1016/j.phytol.2024.03.015

Capnesterones A and B, new steroids isolated from the soft coral Capnella imbricata

Ting Yu Cheng, Chia Jung Yang, Po Jen Chen, Yu Li Chen, Bo Rong Peng, Te An Kung, Zhi Hong Wen, Kuei Hung Lai, Hsu Ming Chung

研究成果: 雜誌貢獻 › 文章 › 同行評審

1 引文斯高帕斯（Scopus）

摘要

Two new non-withanolidal steroids with a cross-conjugated dienone structural unit in ring A, capnesterones A (1) and B (2), were isolated from the soft coral Capnella imbricata in the southeast waters of Taiwan. The compounds' structures were elucidated through a comprehensive analysis of spectroscopic data, including IR, ESIMS, 1H NMR, and 13C NMR, and through comparison with previous literature. At a concentration of 10 μM, steroids 1 and 2 exhibited reductions in iNOS levels (60 % and 82 %) compared to LPS-stimulated control cells, along with increased release (134 % and 110 %) against COX-2 protein expressions.

原文	英語
頁（從 - 到）	115-119
頁數	5
期刊	Phytochemistry Letters
卷	61
DOIs	https://doi.org/10.1016/j.phytol.2024.03.015
出版狀態	已發佈 - 6月 2024

ASJC Scopus subject areas

生物技術
生物化學
農學與作物科學
植物科學

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10.1016/j.phytol.2024.03.015

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Link to publication in Scopus

引用此

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title = "Capnesterones A and B, new steroids isolated from the soft coral Capnella imbricata",

abstract = "Two new non-withanolidal steroids with a cross-conjugated dienone structural unit in ring A, capnesterones A (1) and B (2), were isolated from the soft coral Capnella imbricata in the southeast waters of Taiwan. The compounds' structures were elucidated through a comprehensive analysis of spectroscopic data, including IR, ESIMS, 1H NMR, and 13C NMR, and through comparison with previous literature. At a concentration of 10 μM, steroids 1 and 2 exhibited reductions in iNOS levels (60 % and 82 %) compared to LPS-stimulated control cells, along with increased release (134 % and 110 %) against COX-2 protein expressions.",

keywords = "Capnella imbricata, COX-2, INOS, Steroid",

author = "Cheng, {Ting Yu} and Yang, {Chia Jung} and Chen, {Po Jen} and Chen, {Yu Li} and Peng, {Bo Rong} and Kung, {Te An} and Wen, {Zhi Hong} and Lai, {Kuei Hung} and Chung, {Hsu Ming}",

note = "Publisher Copyright: {\textcopyright} 2024 Phytochemical Society of Europe",

year = "2024",

month = jun,

doi = "10.1016/j.phytol.2024.03.015",

language = "English",

volume = "61",

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journal = "Phytochemistry Letters",

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T1 - Capnesterones A and B, new steroids isolated from the soft coral Capnella imbricata

AU - Cheng, Ting Yu

AU - Yang, Chia Jung

AU - Chen, Po Jen

AU - Chen, Yu Li

AU - Peng, Bo Rong

AU - Kung, Te An

AU - Wen, Zhi Hong

AU - Lai, Kuei Hung

AU - Chung, Hsu Ming

PY - 2024/6

Y1 - 2024/6

N2 - Two new non-withanolidal steroids with a cross-conjugated dienone structural unit in ring A, capnesterones A (1) and B (2), were isolated from the soft coral Capnella imbricata in the southeast waters of Taiwan. The compounds' structures were elucidated through a comprehensive analysis of spectroscopic data, including IR, ESIMS, 1H NMR, and 13C NMR, and through comparison with previous literature. At a concentration of 10 μM, steroids 1 and 2 exhibited reductions in iNOS levels (60 % and 82 %) compared to LPS-stimulated control cells, along with increased release (134 % and 110 %) against COX-2 protein expressions.

AB - Two new non-withanolidal steroids with a cross-conjugated dienone structural unit in ring A, capnesterones A (1) and B (2), were isolated from the soft coral Capnella imbricata in the southeast waters of Taiwan. The compounds' structures were elucidated through a comprehensive analysis of spectroscopic data, including IR, ESIMS, 1H NMR, and 13C NMR, and through comparison with previous literature. At a concentration of 10 μM, steroids 1 and 2 exhibited reductions in iNOS levels (60 % and 82 %) compared to LPS-stimulated control cells, along with increased release (134 % and 110 %) against COX-2 protein expressions.

KW - Capnella imbricata

KW - COX-2

KW - INOS

KW - Steroid

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VL - 61

SP - 115

EP - 119

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

Capnesterones A and B, new steroids isolated from the soft coral Capnella imbricata

摘要

ASJC Scopus subject areas

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