Capnesterones A and B, new steroids isolated from the soft coral Capnella imbricata

Ting Yu Cheng, Chia Jung Yang, Po Jen Chen, Yu Li Chen, Bo Rong Peng, Te An Kung, Zhi Hong Wen, Kuei Hung Lai, Hsu Ming Chung

研究成果: 雜誌貢獻文章同行評審

摘要

Two new non-withanolidal steroids with a cross-conjugated dienone structural unit in ring A, capnesterones A (1) and B (2), were isolated from the soft coral Capnella imbricata in the southeast waters of Taiwan. The compounds' structures were elucidated through a comprehensive analysis of spectroscopic data, including IR, ESIMS, 1H NMR, and 13C NMR, and through comparison with previous literature. At a concentration of 10 μM, steroids 1 and 2 exhibited reductions in iNOS levels (60 % and 82 %) compared to LPS-stimulated control cells, along with increased release (134 % and 110 %) against COX-2 protein expressions.
原文英語
頁(從 - 到)115-119
頁數5
期刊Phytochemistry Letters
61
DOIs
出版狀態已發佈 - 6月 2024

ASJC Scopus subject areas

  • 生物技術
  • 生物化學
  • 農學與作物科學
  • 植物科學

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