Budesonide therapy in preterm infants to prevent bronchopulmonary dysplasia

Shou Y. Wu, Chung M. Chen, Yung T. Kuo, Tsu F. Yeh

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

Severe bronchopulmonary dysplasia (BPD) is common disease, especially for the tiniest infants with gestational age <27 weeks whose mothers did not receive adequate antenatal steroid prophylaxis. Systemic corticosteroids have been demonstrated to be effective in the prevention of BPD, but their adverse effects prevent routine use. The results of inhaled steroid therapy in intubated premature infants are disappointing. In a pilot study, infants in the treatment group who received early intratracheal instillation of budesonide by using surfactant as a vehicle required significantly less ventilator support during the first 2 weeks than infants in the control group. The combined outcome of deaths or BPD was significantly lower in the treatment group than in the control group. No clinically significant adverse effects from the treatment were observed during the study. The results are encouraging, and a large sample multicenter trial is warranted.
原文英語
頁(從 - 到)e467-e475
期刊NeoReviews
13
發行號8
DOIs
出版狀態已發佈 - 8月 2012

ASJC Scopus subject areas

  • 兒科、圍產兒和兒童健康

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